SNS researchers overcome the freezing sample problem in biostudies
October 01, 2012 — Studying biosamples at supercold temperatures, such as 200 Kelvin (-73.15°C), has been impossible in the past, as the water in such solutions inevitably freezes, and with it, the biosample's dynamic interactions. How to keep biosamples from freezing at very low temperatures has been an ongoing research problem—until now.
Martha "cow-laborates" to help unravel protein structure in milk
March 01, 2012 — Casein micelles, a family of related phosphorus-containing proteins, make up 80% of the protein in cow milk. They are the building blocks of dairy products such as yogurt and cheese, supplying amino acids, calcium, and phosphorus to the body. More important, they are the principal vehicle for delivering calcium phosphate to rapidly growing newborns.
Studying how a protein's dynamics can take down a killer
March 01, 2012 — In the 1950s at Minimata, Japan, 900 people died and 2 million suffered life-long injury, in the form of birth defects to incapacitating neurological and muscular deformities, after swimming in and consuming fish from the bay nearby.
Detecting the shape of polymer chains inside polyelectrolyte biomaterials
February 01, 2012 — Researchers at the Bio-SANS instrument at the High Flux Isotope Reactor (HFIR) used small-angle neutron scattering (SANS) to get a first insight into the conformation of single polyelectrolyte chains in large pieces of the synthetic complex.
SANS tracks cell death protein invading biomimetic mitochondrial membrane
December 01, 2011 — An international team of biochemists, biophysicists, and neutron scientists are using a combination of fluorescence and small-angle neutron scattering (SANS) techniques to assist biochemists in better understanding how a protein associated with cell death incorporates into membranes.
Building a Road Map for Tailoring Multilayer Films for Medicine
August 01, 2011 — Polyelectrolytes are water-soluble polymers. They have important applications for controlled drug delivery in medicine and for environmental work such as oil recovery and water treatment.
SANS Detects Contaminants in Insulin, Improving It as a Tool To Study Alzheimer’s
May 01, 2011 — Researchers have long thought that formation of insoluble fibrous “strings” of self-assembling proteins might be involved in the progression of a number of diseases, including neurodegenerative disorders such as Alzheimer’s and Parkinson’s.
First-Ever Sub-Nanoscale Snapshots of Renegade Protein in Huntington’s Disease
May 01, 2011 — An ORNL–University of Tennessee Graduate School of Medicine collaboration has for the first time successfully characterized the earliest structural formation of the disease type of the protein “huntingtin” that creates such havoc in Huntington’s Disease (HD). The incurable, hereditary neurological disorder is always fatal and affects 1 in 10,000 Americans.