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Two hybrid poplar plants, middle and right, engineered with the PtrXB38 hub gene exhibited a drastic increase in root and callus formation compared with a wild-type control plant, left. Credit: Tao Yao/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists identified a gene “hotspot” in the poplar tree that triggers dramatically increased root growth. The discovery supports development of better bioenergy crops and other plants that can thrive in difficult conditions while storing more carbon belowground.

ORNL’s Jack Cahill, Eugene Dumitrescu, Dan Lu, Takaaki Koyanagi and Matthew Brahlek have been selected to receive Department of Energy Early Career Research awards. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy.

Since its inception in 2010, the program bolsters national scientific discovery by supporting early career researchers in fields pertaining to the Office of Science.

Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

Biopsy from the tubular esophagus showing incomplete intestinal metaplasia, goblet cells with interposed cells having gastric foveolar-type mucin consistent with Barrett esophagus. Negative for dysplasia. H&E stain. Credit: Creative Commons

A team including researchers from the Department of Energy’s Oak Ridge National Laboratory has developed a digital tool to better monitor a condition known as Barrett’s esophagus, which affects more than 3 million people in the United States.

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.

Urban climate modeling

Researchers at Oak Ridge National Laboratory have identified a statistical relationship between the growth of cities and the spread of paved surfaces like roads and sidewalks. These impervious surfaces impede the flow of water into the ground, affecting the water cycle and, by extension, the climate.

Computing—Routing out the bugs

A study led by Oak Ridge National Laboratory explored the interface between the Department of Veterans Affairs’ healthcare data system and the data itself to detect the likelihood of errors and designed an auto-surveillance tool

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While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.

A radiologist outfitted with the team’s head-mounted eye-tracking device examines a mammogram. Credit: Hong-Jun Yoon/Oak Ridge National Laboratory, U.S. Dept. of Energy

In an effort to reduce errors in the analyses of diagnostic images by health professionals, a team of researchers from the Department of Energy’s Oak Ridge National Laboratory has improved understanding of the cognitive processes 

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For decades, biologists have believed a key enzyme in plants had one function—produce amino acids, which are vital to plant survival and also essential to human diets. But for Wellington Muchero, Meng Xie and their colleagues, this enzyme does more than advertised. They had run a series of experiments on poplar plants that consistently revealed mutations in a structure of the life-sustaining enzyme that was not previously known to exist.