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ORNL’s Jack Cahill, Eugene Dumitrescu, Dan Lu, Takaaki Koyanagi and Matthew Brahlek have been selected to receive Department of Energy Early Career Research awards. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy.

Since its inception in 2010, the program bolsters national scientific discovery by supporting early career researchers in fields pertaining to the Office of Science.

Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

Biopsy from the tubular esophagus showing incomplete intestinal metaplasia, goblet cells with interposed cells having gastric foveolar-type mucin consistent with Barrett esophagus. Negative for dysplasia. H&E stain. Credit: Creative Commons

A team including researchers from the Department of Energy’s Oak Ridge National Laboratory has developed a digital tool to better monitor a condition known as Barrett’s esophagus, which affects more than 3 million people in the United States.

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.

Urban climate modeling

Researchers at Oak Ridge National Laboratory have identified a statistical relationship between the growth of cities and the spread of paved surfaces like roads and sidewalks. These impervious surfaces impede the flow of water into the ground, affecting the water cycle and, by extension, the climate.

Computing—Routing out the bugs

A study led by Oak Ridge National Laboratory explored the interface between the Department of Veterans Affairs’ healthcare data system and the data itself to detect the likelihood of errors and designed an auto-surveillance tool

A radiologist outfitted with the team’s head-mounted eye-tracking device examines a mammogram. Credit: Hong-Jun Yoon/Oak Ridge National Laboratory, U.S. Dept. of Energy

In an effort to reduce errors in the analyses of diagnostic images by health professionals, a team of researchers from the Department of Energy’s Oak Ridge National Laboratory has improved understanding of the cognitive processes 

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The probe of an atomic force microscope (AFM) scans a surface to reveal details at a resolution 1,000 times greater than that of an optical microscope. That makes AFM the premier tool for analyzing physical features, but it cannot tell scientists anything about chemistry. For that they turn to the mass spectrometer (MS).
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From the bluebird painting propped against her office wall and the deer she mentions seeing outside her office window, Linda Lewis might be mistaken for a wildlife biologist at first glance. But rather than trailing animal tracks, Lewis, a researcher at the Department of Energy’s Oak Ridge National Laboratory, is more interested in marks left behind by humans.

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With more than 30 patents, James Klett is no stranger to success, but perhaps the Oak Ridge National Laboratory researcher’s most noteworthy achievement didn’t start out so hot – or so it seemed at the time.