Many new nuclear data needs are emerging in areas where data are poorly quantified, especially for advanced reactors, isotope production, and nuclear security applications. With limited science facilities remaining for nuclear data measurements, ORNL teams work broadly throughout the community to utilize the best-available facilities for the targeted need. When coupled with our nuclear data evaluation and process capabilities and modeling and simulation tools for validation, high-quality nuclear data evaluations with associated uncertainties can be generated to improve previous results or to close gaps in nuclear data to address new needs. Through the application of SCALE’s S/U tools, nuclear data needs are identified and prioritized to maximize the limited resources available to improve nuclear data libraries.