Abstract
Application of PAL protocols was performed for acrylonitrile, as experimental data permitted. Human data were limited to inhalation exposures. The animal experimental data set for this chemical was robust for inhalation and oral studies, with the exception of appropriate data for inhalation 30-d, 90-d, and 2-yr PAL 3 values. PAL estimates were approved by the Expert Consultation Panel for Provisional Advisory Levels in October 2007.
Oral 24-hr PALs for acrylonitrile are: PAL 1 = 7 mg/L; PAL 2 = 23 mg/L; and PAL 3 = 88 mg/L. Oral 30-d and 90-d PALs are: PAL 1 = 0.35 mg/L; PAL 2 = 7 mg/L; and PAL 3 = 17 mg/L. Oral 2-yr PALs are: PAL 1 = 0.35 mg/L; PAL 2 = 3.5 mg/L; and PAL 3 = 12 mg/L. Acrylonitrile inhalation PAL values for 24 hr exposure are: PAL 1 = 0.17 ppm; PAL 2 = 3.5 ppm; and PAL 3 = 5.1 ppm; the 30-d and 90-d inhalation exposure values are: PAL 1 = 0.15 ppm and PAL 2 = 0.60 ppm. The 2-yr inhalation values are: PAL 1 = 0.014 ppm and PAL 2 = 0.12 ppm. PAL 3 values for 30-d, 90-d, and 2-yr are not recommended due to insufficient data.