Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
An informal off-site informatics meeting was held on November 15, 1994, as an adjunct to the DOE Human Genome Program Contractor-Grantee Workshop in Santa Fe, New Mexico. The discussion at the National Center for Genome Resources involved about 25 NIH and DOE investigators. Its purpose was to develop ideas and a working plan for an interoperable framework of genome-analysis tools. An earlier discussion on this topic was organized by David States at the Cold Spring Harbor Genome Mapping and Sequencing meeting in May 1994 [see HGN 6(4), 16 (November 1994)]. As in the earlier session, the group strongly agreed about the desirability of a framework to provide researchers with seamless and transparent access to an array of sequence-analysis tools and databases.
The Santa Fe meeting centered around a plan to develop a multiple-client environment that could access a variety of Internet servers. It would facilitate genome analysis and data retrieval, entry, and annotation, transparently passing data types and control among the various tools. In this approach, individual tool designers would attach their servers to the framework by submitting a client code and information about their server and input-output data types to a central library. The modular, flexible framework would allow growth and new types of analysis and data and facilitate community-wide interoperability.
Several goals were reached at the meeting:
The prototype would demonstrate several major project goals, including the ability to navigate and access distributed Internet tools within a single environment, exchange data among tools, and use interoperable systems for data retrieval, analysis, and annotation. The group hoped the prototype would be available by May, when members will reconvene at the Cold Spring Harbor meeting.
Comments to the group and information requests may be sent to FTFNAMES@mars.epm.ornl.gov. A Mosaic page related to the project can be accessed at http://avalon.epm.ornl.gov:80/FTF.
Edward Uberbacher, Oak Ridge National Laboratory
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Human Genome Program, U.S. Department of Energy, Human Genome News (v6n6).
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