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Cascade alkylation and deuteration with aryl iodides via Pd/norbornene catalysis: an efficient method for the synthesis of co...

Publication Type
Journal
Journal Name
Chemical Communications
Publication Date
Page Numbers
8567 to 8570
Volume
55
Issue
59

An efficient approach for synthesizing congested deuterium-labeled arenes via cascade alkylation and deuteration with aryl iodides has been disclosed. We found that the adoption of sodium formate-d as a deuterium source is the key for achieving high deuterium incorporation >98%.