Publication Type
Journal
Journal Name
Age (Omaha)
Publication Date
Page Numbers
75 to 90
Volume
27
Issue
1
Abstract
With the goal of discovering genes that contribute to late-onset neurological and ocular disorders and also genes
that extend the healthy life span in mammals, we are phenotyping mice carrying new mutations induced by the
chemical N-ethyl-N-nitrosourea (ENU). The phenotyping plan includes basic behavioral, neurohistological, and
vision testing in sibling cohorts of mice aged to 18 months, and then evaluation for markers of growth trajectory
and stress response in these same cohorts aged up to 28 months. Statistical outliers are identified by comparison to test results of similar aged cohorts, and potential mutants are recovered for re-aging to confirm heritability of the phenotype.