Skip to main content
SHARE
Publication

Synthesis of N1-tritylethane-1,1,2,2-d4-1,2-diamine: a novel mono-protected C-deuterated ethylenediamine synthon...

by Jun Yang, Kunlun Hong, Peter V Bonnesen
Publication Type
Journal
Journal Name
Journal of Labelled Compounds and Radiopharmaceuticals
Publication Date
Page Numbers
463 to 466
Volume
55
Issue
13

A convenient and high-yield synthesis for N1-tritylethane-1,1,2,2-d4-1,2-diamine, a novel mono-protected ethylenediamine-C-d4, is reported. N1-tritylethane-1,1,2,2-d4-1,2-diamine was prepared in three steps from ethylene oxide-d4 in a combined yield in the range 68-76%. Also reported is a synthesis of ethylenediamine-C-d4 in two steps from 1,2-dibromoethane-d4 in a combined yield in the range 61-65%.