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Theoretical modeling on the kinetics of the arsenate-ester hydrolysis: implications to the stability of As-DNA...

by Miguel A Fuentes-cabrera, Jiri Sponer, Bobby G Sumpter, Arnost Mladek
Publication Type
Journal
Journal Name
Physical Chemistry Chemical Physics
Publication Date
Page Numbers
10869 to 10871
Volume
13
Issue
23

Quantum chemical calculations reveal that neither steric
hindrance nor less polar solvent medium is able to reduce the
otherwise high hydrolysis rate of arsenate-esters. These results
question the stability of As-DNA not only in aqueous but also in
non-aqueous environments.