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Vinyl Dimethyl Azlactone-Containing Copolymers: Towards Bio-Inspired Surfaces/Polymer-Protein Conjugates...

by Jamie M Messman, Abigail Banaszak, Joshua Barrninger, Jimmy W Mays, Sidney M Kilbey Ii
Publication Type
Conference Paper
Publication Date
Conference Name
The Waterborne Symposium Advances in Intelligent Coatings Design
Conference Location
New Orleans, Louisiana, United States of America
Conference Date
-

Stimuli-responsive, vinyl dimethyl azlactone/vinyl pyrrolidone (VDMA/VP) copolymers have been prepared using free radical polymerization techniques. These copolymers are subsequently the basis for the design of polymer brushes where the system is composed of a polystyrene (PS) block and a VDMA/VP copolymer block. Copolymers have been prepared using reversible addition fragmentation chain transfer (RAFT) polymerization technique. Using a solvent that is selective for the VDMA/VP block, these PS-block-P[VDMA/VP] copolymers can be preferentially adsorbed at the solid-fluid interface through the PS block to form a polymer "brush". Because VDMA is known to quantitatively react with amines, exposure of the copolymer to a solution containing amino acids (e.g. glycine) yields a bio-functionalized polymer brush. In this paper we will report on the synthesis and characterization of VDMA/VP copolymers including compositional analysis using FTIR and NMR spectroscopies.