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ORNL has developed a tightly controlled inducible promoter that can activate gene expression in a time- and dose-dependent manner in the thermophilic bacterium C. thermocellum.
The technologies described provides for the upcycling of mixed plastics to muonic acid and 3-hydroxyacids.
This invention is for bacterial strains that can utilize lignocellulose sugars. This will improve the efficiency of bioproduct formation in these strains and reduce the greenhouse-gas emission of an industrial bi
Orphan bHLH enhances plant biomass gain. The orphan bHLH gene has an exclusive nuclear subcellular localization with a transcriptional activator activity.
ORNL has developed bacterial strains that can utilize a common plastic co-monomer as a feedstock. This will help enable modern, petroleum-derived plastics to be converted into value-added chemicals.
Direct-acting antivirals are needed to combat coronavirus disease 2019 (COVID-19), which is caused by severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2).
Biocompatible nanoparticles have been developed that can trap and retain therapeutic radionuclides and their byproducts at the cancer site. This is important to maximize the therapeutic effect of this treatment and minimize associated side effects.
Due to a genes unique nucleotide sequences acquired through horizontal gene transfer, the gene has a transcriptional repressor activity and innate enzymatic role.
We have developed bacterial strains that can convert sustainable feedstocks and waste feedstocks into chemical precursors for next generation plastics.
Genetic modification of microbes that are thermophiles—ones that grow at elevated temperatures—is extremely challenging. Tools developed for E. coli, a typical host for protein production, typically do not function at elevated temperatures.