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Pictured is the IMAGINE instrument at the High Flux Isotope Reactor

Biochemist David Baker — just announced as a recipient of the Nobel Prize for Chemistry — turned to the High Flux Isotope Reactor (HFIR) at Oak Ridge National Laboratory for information he couldn’t get anywhere else. HFIR is the strongest reactor-based neutron source in the United States.  

Graphic of Jordan Cannon

Jordan Cannon is CEO of Circular Biosciences, a Cohort 2024 Innovation Crossroads company, a startup dedicated to accelerating bioplastic degradation for more widespread use, easier disposal and reduced environmental impact. 

Illustration of a hydrogen atom.

Scientists at ORNL used neutrons to end a decades-long debate about an enzyme cancer uses.

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After retiring from Y-12, Scott Abston joined the Isotope Science and Engineering Directorate to support isotope production and work with his former manager. He now leads a team maintaining critical equipment for medical and space applications. Abston finds fulfillment in mentoring his team and is pleased with his decision to continue working.

Jeremiah Sewell

Jeremiah Sewell leads a team at ORNL, working on xenon-129 production for lung imaging. Reflecting on his career, Sewell views each opportunity as a "door" he steps through, leveraging over 25 years of experience in nuclear power and centrifuge operations to advance the facility’s mission.

Man is leaning against the window, arms crossed in a dark navy button up.

Brian Sanders is focused on impactful, multidisciplinary science at Oak Ridge National Laboratory, developing solutions for everything from improved imaging of plant-microbe interactions that influence ecosystem health to advancing new treatments for cancer and viral infections. 

Three team members looking at plants stand in front of a mountain scene, two are in orange safety vests.

When Oak Ridge National Laboratory's science mission takes staff off-campus, the lab’s safety principles follow. That’s true even in the high mountain passes of Washington and Oregon, where ORNL scientists are tracking a tree species — and where wildfires have become more frequent and widespread.

Man in blue shirt and grey pants holds laptop and poses next to a green plant in a lab.

John Lagergren, a staff scientist in Oak Ridge National Laboratory’s Plant Systems Biology group, is using his expertise in applied math and machine learning to develop neural networks to quickly analyze the vast amounts of data on plant traits amassed at ORNL’s Advanced Plant Phenotyping Laboratory.

ORNL researcher Felicia Gilliland loads experiment samples into position for the newly installed UR5E robotic arm at the BIO-SANS instrument. The industrial-grade robot changes samples automatically, reducing the need for human assistance and improving sample throughput. Credit: Jeremy Rumsey/ORNL, U.S. Dept. of Energy

The BIO-SANS instrument, located at Oak Ridge National Laboratory’s High Flux Isotope Reactor, is the latest neutron scattering instrument to be retrofitted with state-of-the-art robotics and custom software. The sophisticated upgrade quadruples the number of samples the instrument can measure automatically and significantly reduces the need for human assistance.

The Linac Coherent Light Source at DOE’s SLAC National Accelerator Laboratory in California reveals the structural dynamics of atoms and molecules through X-ray snapshots at ultrafast timescales. Pictured here is the LCLS-II tunnel. Credit: Jim Gensheimer/SLAC National Accelerator Laboratory

Plans to unite the capabilities of two cutting-edge technological facilities funded by the Department of Energy’s Office of Science promise to usher in a new era of dynamic structural biology. Through DOE’s Integrated Research Infrastructure, or IRI, initiative, the facilities will complement each other’s technologies in the pursuit of science despite being nearly 2,500 miles apart.