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Scientists at ORNL have developed a first-ever method of detecting ribonucleic acid, or RNA, inside plant cells using a technique that results in a visible fluorescent signal. The technology can help researchers detect and track changes in RNA and gene expression in real time, providing a powerful tool for the development of hardier bioenergy and food crops and for detection of unwanted plant modifications, pathogens and pests.  

A deep look inside a cell membrane showing the production of materials from plant biomass, shown with shapes that consist of four green balls connected with a red ball on one end, dotted with smaller white balls on each surface.

Scientists at ORNL and the University of Cincinnati achieved a breakthrough in understanding the vulnerability of microbes to the butanol they produce during fermentation of plant biomass. The discovery could pave the way for more efficient production of domestic fuels, chemicals and materials.

A cargo ship to the left of the seaport with bright blue metal surrounding it

In collaboration with the U.S. Department of Homeland Security’s Science and Technology Directorate, researchers at ORNL are evaluating technology to detect compounds emitted by pathogens and pests in agricultural products at the nation’s border. 

Different groups of proteins shown in different colors combine and attach to a broken strand of DNA.

Researchers at Georgia State University used the Summit supercomputer to study an elaborate molecular pathway called nucleotide excision repair. Decoding NER’s sophisticated sequence of events and the role of PInC in the pathway could provide key insights into developing novel treatments and preventing conditions that lead to premature aging and certain types of cancer.

Three egg-shaped orbs of varying opacity are shown on a dark blue background, increasing transparency revealing they are filled with smaller round balls of red and blue. Arrows indicate counterclockwise rotation of the orbs, and green squiggles imply motion of the smaller balls.

Using the Frontier supercomputer at ORNL, researchers have developed a new technique that predicts nuclear properties in record detail. The study revealed how the structure of a nucleus relates to the force that holds it together. This understanding could advance efforts in quantum physics and across a variety of sectors, from to energy production to national security.

Computer rendering of the FRIB Decay Station initiator, featuring cylindrical components, vacuum chambers, and a greenish glow, used to measure the decays of exotic isotopes at FRIB.

Scientists at ORNL are using advanced germanium detectors to explore fundamental questions in nuclear physics, such as the nature of neutrinos and the matter-antimatter imbalance. The ongoing LEGEND project, an international collaboration, aims to discover neutrinoless double beta decay, which could significantly advance the understanding of the universe.

A male researcher is standing next to a poster board displayed on an easel to the right. The researcher is dressed in professional attire, and the poster board is positioned beside him, showing research or visual information.

Ryan Culler is the program manager at Oak Ridge National Laboratory, where he oversees the production of actinium-225, a promising treatment for cancer. Driven by a personal connection to cancer through his late brother, Culler is dedicated to advancing medical isotopes to help improve cancer care. 

ORNL’s Askin Guler Yigitoglu presents during the 2024 Molten Salt Reactor Workshop in Knoxville with a green and blue background

ORNL’s annual workshop has become the premier forum for molten salt reactor, or MSR, collaboration and innovation, convening industry, academia and government experts to further advance MSR research and development. This year’s event attracted a record-breaking 365 participants from across the country, highlighting the momentum to bring MSRs online.

Summit Supercomputer

Scientists conducted a groundbreaking study on the genetic data of over half a million U.S. veterans, using tools from the Oak Ridge National Laboratory to analyze 2,068 traits from the Million Veteran Program.

A graphical representation about a gene in a poplar tree. There is a close up of a tree to the right and the far left-top corner. There is a strand of DNA going down the middle of the image with an ant and two small circles showing the organisms inside the DNA

A team of scientists with two Department of Energy Bioenergy Research Centers — the Center for Bioenergy Innovation at Oak Ridge National Laboratory and the Center for Advanced Bioenergy and Bioproducts Innovation at the University of Illinois Urbana-Champaign — identified a gene in a poplar tree that enhances photosynthesis and can boost tree height by about 30% in the field and by as much as 200% in the greenhouse.