Progress, and Applications
of the Human Genome Project
Sponsored by the U.S. Department of Energy Human Genome Program
Human Genome News Archive Edition
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Human MHC Region Sequenced
Key to Transplant Rejection, Autoimmune Disease
Sequencing of the 4-Mb human Major Histocompatibility Complex (MHC) region of chromosome6 has been completed by the Sanger Centre, University of Washington, and Tokai University (www.sanger.ac.uk/HGP/Chr6/MHC.shtml).
Proteins encoded by genes residing in the MHC region are responsible for helping the body defend itself against microscopic invaders by distinguishing normal body constituents ("self") from everything else, which it then marks for extinction. Researchers hope that a better understanding of MHC proteins will lead to the development of new ways to minimize transplant rejection and fight such infectious and autoimmune diseases as arthritis and juvenile diabetes.
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Last modified: Wednesday, October 29, 2003
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