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![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![(From left) ORNL Associate Laboratory Director for Computing and Computational Sciences Jeff Nichols; ORNL Health Data Sciences Institute Director Gina Tourassi; DOE Deputy Under Secretary for Science Thomas Cubbage; ORNL Task Lead for Biostatistics Blair Christian; and ORNL Research Scientist Ioana Danciu were invited to the White House to showcase an ORNL-developed digital tool aimed at better matching cancer patients with clinical trials.](/sites/default/files/styles/list_page_thumbnail/public/2019-03/TourassiWH%5B1%5D.png?h=26b5064d&itok=HUC2iYmE)
OAK RIDGE, Tenn., March 4, 2019—A team of researchers from the Department of Energy’s Oak Ridge National Laboratory Health Data Sciences Institute have harnessed the power of artificial intelligence to better match cancer patients with clinical trials.
OAK RIDGE, Tenn., Feb. 12, 2019—A team of researchers from the Department of Energy’s Oak Ridge and Los Alamos National Laboratories has partnered with EPB, a Chattanooga utility and telecommunications company, to demonstrate the effectiveness of metro-scale quantum key distribution (QKD).
![Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing. Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing.](/sites/default/files/styles/list_page_thumbnail/public/2018-P09551.jpg?itok=q7Ri01Qb)
Scientists at the Department of Energy’s Oak Ridge National Laboratory have created a recipe for a renewable 3D printing feedstock that could spur a profitable new use for an intractable biorefinery byproduct: lignin.
![Oak Ridge National Laboratory’s Summit supercomputer was named No. 1 on the TOP500 List, a semiannual ranking of the world’s fastest computing systems. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy.Oak Ridge National Laboratory’ Oak Ridge National Laboratory’s Summit supercomputer was named No. 1 on the TOP500 List, a semiannual ranking of the world’s fastest computing systems. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2018-P03971.jpg?itok=BNeaoWKB)
The US Department of Energy’s Oak Ridge National Laboratory is once again officially home to the fastest supercomputer in the world, according to the TOP500 List, a semiannual ranking of the world’s fastest computing systems.
![Oak Ridge National Laboratory launches Summit supercomputer. Oak Ridge National Laboratory launches Summit supercomputer.](/sites/default/files/styles/list_page_thumbnail/public/2018-P01537.jpg?itok=GLf4y1EZ)
The U.S. Department of Energy’s Oak Ridge National Laboratory today unveiled Summit as the world’s most powerful and smartest scientific supercomputer.
![Graphical representation of a deuteron, the bound state of a proton (red) and a neutron (blue). Credit: Andy Sproles/Oak Ridge National Laboratory, U.S. Dept. of Energy. Graphical representation of a deuteron, the bound state of a proton (red) and a neutron (blue). Credit: Andy Sproles/Oak Ridge National Laboratory, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/news/images/deuteron%5B4%5D.jpg?itok=hEV9C82i)
Scientists at the Department of Energy’s Oak Ridge National Laboratory are the first to successfully simulate an atomic nucleus using a quantum computer. The results, published in Physical Review Letters, demonstrate the ability of quantum systems to compute nuclear ph...
![ORNL’s Steven Young (left) and Travis Johnston used Titan to prove the design and training of deep learning networks could be greatly accelerated with a capable computing system. ORNL’s Steven Young (left) and Travis Johnston used Titan to prove the design and training of deep learning networks could be greatly accelerated with a capable computing system.](/sites/default/files/styles/list_page_thumbnail/public/news/images/RAvENNA%20release%20pic.png?itok=2bDpK5Mo)
A team of researchers from the Department of Energy’s Oak Ridge National Laboratory has married artificial intelligence and high-performance computing to achieve a peak speed of 20 petaflops in the generation and training of deep learning networks on the