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An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

This protein drives key processes for sulfide use in many microorganisms that produce methane, including Thermosipho melanesiensis. Researchers used supercomputing and deep learning tools to predict its structure, which has eluded experimental methods such as crystallography.  Credit: Ada Sedova/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory and the Georgia Institute of Technology is using supercomputing and revolutionary deep learning tools to predict the structures and roles of thousands of proteins with unknown functions.

By wet-sieving stream sediment, (from left) Oak Ridge National Laboratory’s Kenneth Lowe, Melanie Mayes and John Dickson sort sediment into different particle size in this stream near Rocky Top.

An Oak Ridge National Laboratory study is providing an unprecedented watershed-scale understanding of mercury in soils and sediments. Researchers focused on evaluating mercury and soil properties along the banks of a mercury-contaminated stream in Oak Ridge, Tenn., sampling 145 loca...

Andrew King loads a gel with amplified gene fragments to detect the presence of mercury methylation genes in samples from East Fork Poplar Creek in Oak Ridge.

Environmental scientists can more efficiently detect genes required to convert mercury in the environment into more toxic methylmercury with molecular probes developed by researchers at the Department of Energy’s Oak Ridge National Laboratory. “We now have a quic...