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![A Co-Optima research team led by Oak Ridge National Laboratory’s Jim Szybist in collaboration with Argonne, Sandia and the National Renewable Energy Laboratory, created a merit function tool that evaluates six fuel properties and their impact on engine performance, giving the scientific community a guide to quickly evaluate biofuels. Credit: ORNL/U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-12/2017-P08539-2_0.jpg?h=b6236d98&itok=h0OT2BqC)
As ORNL’s fuel properties technical lead for the U.S. Department of Energy’s Co-Optimization of Fuel and Engines, or Co-Optima, initiative, Jim Szybist has been on a quest for the past few years to identify the most significant indicators for predicting how a fuel will perform in engines designed for light-duty vehicles such as passenger cars and pickup trucks.
![Sandra Davern performs cell based assays to evaluate cell death and DNA damage in response to radiation in order to gain a better understanding of how radioisotope nanoparticles affect the human body.](/sites/default/files/styles/list_page_thumbnail/public/2020-10/2020-P15712.jpg?h=036a71b7&itok=6cpxN4v2)
When Sandra Davern looks to the future, she sees individualized isotopes sent into the body with a specific target: cancer cells.
![A structural model of HgcA, shown in cyan, and HgcB, shown in purple, were created using metagenomic techniques to better understand the transformation of mercury into its toxic form, methylmercury. Photo credit: Connor Cooper/ORNL, U.S. Dept of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-08/methylmercury%20protein%20folding_0.png?h=4a7d1ed4&itok=fWObhykl)
A team led by ORNL created a computational model of the proteins responsible for the transformation of mercury to toxic methylmercury, marking a step forward in understanding how the reaction occurs and how mercury cycles through the environment.
![Enzyme activity during organophosphate poisoning](/sites/default/files/styles/list_page_thumbnail/public/2020-08/anecdote1_0.png?h=d1cb525d&itok=wpYYilBI)
Pick your poison. It can be deadly for good reasons such as protecting crops from harmful insects or fighting parasite infection as medicine — or for evil as a weapon for bioterrorism. Or, in extremely diluted amounts, it can be used to enhance beauty.
![Computational biophysicist Ada Sedova is using experiments and high-performance computing to explore the properties of biological systems and predict their form and function, including research to accelerate drug discovery for COVID-19. Photo credit: Jason Richards, Oak Ridge National Laboratory, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2020-07/2017-P06162Cropped.jpg?h=f1d4573a&itok=TrvR_opt)
Ada Sedova’s journey to Oak Ridge National Laboratory has taken her on the path from pre-med studies in college to an accelerated graduate career in mathematics and biophysics and now to the intersection of computational science and biology
![Ecosystem Ecologist Verity Salmon captures and analyzes field data from sites in in Alaska and Minnesota to inform earth system models that are being used to predict environmental change.](/sites/default/files/styles/list_page_thumbnail/public/2020-04/Salmon_CreditColleenIversen_0.jpg?h=6eb229a4&itok=cjwhvth8)
While some of her earth system modeling colleagues at ORNL face challenges such as processor allocation or debugging code, Verity Salmon prepares for mosquito swarms and the possibility of grizzly bears.
![Suman Debnath](/sites/default/files/styles/list_page_thumbnail/public/2020-04/SumanDebnathThumb.jpg?h=38099c27&itok=_Eq7kvb6)
Suman Debnath, a researcher at ORNL, has been elevated to the grade of senior member of the Institute of Electrical and Electronics Engineers (IEEE).
![Coronavirus graphic](/sites/default/files/styles/list_page_thumbnail/public/2020-04/covid19_jh_0.png?h=d1cb525d&itok=PyngFUZw)
In the race to identify solutions to the COVID-19 pandemic, researchers at the Department of Energy’s Oak Ridge National Laboratory are joining the fight by applying expertise in computational science, advanced manufacturing, data science and neutron science.
![Researchers discovered the Tennessee cavesnail, Antrorbis tennesseensis, in caves near Oak Ridge National Laboratory. The snail measures in at less than 2 millimeters long. Credit: Nathaniel Shoobs and Matthew Niemiller](/sites/default/files/styles/list_page_thumbnail/public/2020-04/Cave_snailREV.jpg?h=c96bab7a&itok=6rjc3NQL)
Sometimes conducting big science means discovering a species not much larger than a grain of sand.
![Scientists created a novel polymer that is as effective as natural proteins in transporting protons through a membrane. Credit: ORNL/Jill Hemman](/sites/default/files/styles/list_page_thumbnail/public/2020-03/19-G01195_nature_feature_0.png?h=e4fbc3eb&itok=K8czXmTr)
Biological membranes, such as the “walls” of most types of living cells, primarily consist of a double layer of lipids, or “lipid bilayer,” that forms the structure, and a variety of embedded and attached proteins with highly specialized functions, including proteins that rapidly and selectively transport ions and molecules in and out of the cell.