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Jack Cahill of ORNL’s Biosciences Division is developing new techniques to view and measure the previously unseen to better understand important chemical processes at play in plant-microbe interactions and in human health. In this photo, Cahill is positioning a rhizosphere-on-a-chip platform for imaging by mass spectrometry. Credit: Carlos Jones/ORNL, U.S. Dept of Energy

John “Jack” Cahill is out to illuminate previously unseen processes with new technology, advancing our understanding of how chemicals interact to influence complex systems whether it’s in the human body or in the world beneath our feet.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Researchers at Oak Ridge National Laboratory designed an adsorbent material to rapidly remove toxic chromium and arsenic simultaneously from water resources. Credit: Adam Malin/ORNL, U.S. Dept. of Energy

Researchers at ORNL are tackling a global water challenge with a unique material designed to target not one, but two toxic, heavy metal pollutants for simultaneous removal.

Samarthya Bhagia examines a sample of a thermoplastic composite material additively manufactured using poplar wood and polylactic acid. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Chemical and environmental engineer Samarthya Bhagia is focused on achieving carbon neutrality and a circular economy by designing new plant-based materials for a range of applications from energy storage devices and sensors to environmentally friendly bioplastics.

Oak Ridge National Laboratory scientists are enhancing the performance of polymer materials for next-generation lithium batteries. Credit: Adam Malin/ORNL, U.S. Dept. of Energy

Researchers at Oak Ridge National Laboratory are using state-of-the-art methods to shed light on chemical separations needed to recover rare-earth elements and secure critical materials for clean energy technologies.

The ORNL researchers’ findings may enable better detection of uranium tetrafluoride hydrate, a little-studied byproduct of the nuclear fuel cycle, and better understanding of how environmental conditions influence the chemical behavior of fuel cycle materials. Credit: Kevin Pastoor/Colorado School of Mines

ORNL researchers used the nation’s fastest supercomputer to map the molecular vibrations of an important but little-studied uranium compound produced during the nuclear fuel cycle for results that could lead to a cleaner, safer world.

Virginia-based battery technology company, BTRY, has licensed several electrolyte and thin-film coating technologies, developed at Oak Ridge National Laboratory, to make batteries with increased energy density, at lower cost, and with an improved safety profile in crashes. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Several electrolyte and thin-film coating technologies, developed at Oak Ridge National Laboratory, have been licensed by BTRY, a battery technology company based in Virginia, to make batteries with increased energy density, at lower cost, and with an improved safety profile in crashes.

Elizabeth Herndon uses spectroscopic techniques at ORNL to analyze the chemical composition of leaves and other environmental samples to better understand the soil carbon cycle. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

ORNL biogeochemist Elizabeth Herndon is working with colleagues to investigate a piece of the puzzle that has received little attention thus far: the role of manganese in the carbon cycle.

Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.