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Media Contacts
![Researchers studying secondary metabolites in the fungus Aspergillus flavus, pictured, found unique mixes of metabolites corresponding to genetically distinct populations. The finding suggests local environmental conditions play a key role in secondary metabolite production, influencing the discovery of drugs and other useful compounds. Credit: Tomás Allen Rush/ORNL, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2021-07/DSC0351.jpg?h=b2d9f031&itok=PNgYY5eW)
Scientists at ORNL and the University of Wisconsin–Madison have discovered that genetically distinct populations within the same species of fungi can produce unique mixes of secondary metabolites, which are organic compounds with applications in
![An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-06/frame1.png?h=d1cb525d&itok=51pwBWyP)
An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.
![A research team led by ORNL’s Xiaohan Yang used a gene from agave to engineer higher yield, improved stress tolerance and greater carbon sequestration in tobacco plants. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-06/2019-P09831.jpg?h=39b94f55&itok=8O8d7xMb)
Scientists at ORNL have discovered a single gene that simultaneously boosts plant growth and tolerance for stresses such as drought and salt, all while tackling the root cause of climate change by enabling plants to pull more carbon dioxide from the atmosphere.
![Belinda Akpa applies her diverse expertise and high-performance computing to accelerate the drug discovery process and increase the chances of success when candidate molecules go to clinical trials. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-04/2021-P02772_1.jpg?h=0a8b6f8b&itok=seLu5znj)
Belinda Akpa is a chemical engineer with a talent for tackling big challenges and fostering inclusivity and diversity in the next generation of scientists.
![Rich Giannone uses bioanalytical mass spectrometry to examine proteins, the primary driver in biological systems.](/sites/default/files/styles/list_page_thumbnail/public/2021-04/2021-P02194_small.jpg?h=c6980913&itok=bc6MRBX6)
Rich Giannone uses bioanalytical mass spectrometry to examine proteins, the primary driver in biological systems.
![ATOM logo](/sites/default/files/styles/list_page_thumbnail/public/2021-03/ATOM_Logo_small.png?h=8f9cfe54&itok=Qpezfk8V)
The Accelerating Therapeutics for Opportunities in Medicine , or ATOM, consortium today announced the U.S. Department of Energy’s Oak Ridge, Argonne and Brookhaven national laboratories are joining the consortium to further develop ATOM’s artificial intelligence, or AI-driven, drug discovery platform.
![ORNL recognized the small businesses that have made a positive impact on ORNL’s operations at the virtual 2020 Small Business Awards. Credit: ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-11/2013-P05160-cropped_0.jpg?h=8f74817f&itok=VU4aJf_i)
Thirty-two Oak Ridge National Laboratory employees were named among teams recognized by former DOE Secretary Dan Brouillette with Secretary’s Honor Awards as he completed his term. Four teams received new awards that reflect DOE responses to the coronavirus pandemic.
![Frontier supercomputer](/sites/default/files/styles/list_page_thumbnail/public/2023-01/frontier_0.jpg?h=a1e1a043&itok=J3IM_Xeh)
A multi-institutional team, led by a group of investigators at Oak Ridge National Laboratory, has been studying various SARS-CoV-2 protein targets, including the virus’s main protease. The feat has earned the team a finalist nomination for the Association of Computing Machinery, or ACM, Gordon Bell Special Prize for High Performance Computing-Based COVID-19 Research.
![coronavirus](/sites/default/files/styles/list_page_thumbnail/public/2020-11/coronavirus_top10%20%28002%29.png?h=997b30da&itok=7I6TjG_l)
NellOne Therapeutics has licensed a drug delivery system from the Department of Energy’s Oak Ridge National Laboratory that is designed to transport therapeutics directly to cells infected by SARS-CoV-2, the virus causing COVID-19.
![Sandra Davern performs cell based assays to evaluate cell death and DNA damage in response to radiation in order to gain a better understanding of how radioisotope nanoparticles affect the human body.](/sites/default/files/styles/list_page_thumbnail/public/2020-10/2020-P15712.jpg?h=036a71b7&itok=6cpxN4v2)
When Sandra Davern looks to the future, she sees individualized isotopes sent into the body with a specific target: cancer cells.