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Media Contacts
![Computational biophysicist Ada Sedova is using experiments and high-performance computing to explore the properties of biological systems and predict their form and function, including research to accelerate drug discovery for COVID-19. Photo credit: Jason Richards, Oak Ridge National Laboratory, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2020-07/2017-P06162Cropped.jpg?h=f1d4573a&itok=TrvR_opt)
Ada Sedova’s journey to Oak Ridge National Laboratory has taken her on the path from pre-med studies in college to an accelerated graduate career in mathematics and biophysics and now to the intersection of computational science and biology
![The protease protein is both shaped like a heart and functions as one, allowing the virus replicate and spread. Inhibiting the protease would block virus reproduction. Credit: Andrey Kovalevsky/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-06/protease_dimer_3_1.png?h=aa51a450&itok=sJY7AB8d)
A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.
![At the U.S. Department of Energy Manufacturing Demonstration Facility at ORNL, this part for a scaled-down prototype of a reactor was produced for industry partner Kairos Power.](/sites/default/files/styles/list_page_thumbnail/public/2020-05/Kairos%20PI%201_0.jpg?h=71976bb4&itok=EYVPB9H3)
Scientists at the Department of Energy Manufacturing Demonstration Facility at ORNL have their eyes on the prize: the Transformational Challenge Reactor, or TCR, a microreactor built using 3D printing and other new approaches that will be up and running by 2023.
![Omar Demerdash](/sites/default/files/styles/list_page_thumbnail/public/2020-05/demerdash_crop.jpg?h=8831409f&itok=2J2gUqDr)
With the rise of the global pandemic, Omar Demerdash, a Liane B. Russell Distinguished Staff Fellow at ORNL since 2018, has become laser-focused on potential avenues to COVID-19 therapies.
![Transformational Challenge Reactor Demonstration items](/sites/default/files/styles/list_page_thumbnail/public/2020-03/Press_release_image.jpg?h=b707efd5&itok=-Sxbmt8D)
Researchers at the Department of Energy’s Oak Ridge National Laboratory are refining their design of a 3D-printed nuclear reactor core, scaling up the additive manufacturing process necessary to build it, and developing methods
![Coronavirus graphic](/sites/default/files/styles/list_page_thumbnail/public/2020-04/covid19_jh_0.png?h=d1cb525d&itok=PyngFUZw)
In the race to identify solutions to the COVID-19 pandemic, researchers at the Department of Energy’s Oak Ridge National Laboratory are joining the fight by applying expertise in computational science, advanced manufacturing, data science and neutron science.
![VERA’s tools allow a virtual “window” inside the reactor core, down to a molecular level.](/sites/default/files/styles/list_page_thumbnail/public/2020-03/core.png?h=dc920c3f&itok=BggaFrQA)
A software package, 10 years in the making, that can predict the behavior of nuclear reactors’ cores with stunning accuracy has been licensed commercially for the first time.
![Coronavirus research](/sites/default/files/styles/list_page_thumbnail/public/2020-03/still_original.png?h=d1cb525d&itok=0Md1n6Ct)
Researchers at the Department of Energy’s Oak Ridge National Laboratory have used Summit, the world’s most powerful and smartest supercomputer, to identify 77 small-molecule drug compounds that might warrant further study in the fight
![Scientists created a novel polymer that is as effective as natural proteins in transporting protons through a membrane. Credit: ORNL/Jill Hemman](/sites/default/files/styles/list_page_thumbnail/public/2020-03/19-G01195_nature_feature_0.png?h=e4fbc3eb&itok=K8czXmTr)
Biological membranes, such as the “walls” of most types of living cells, primarily consist of a double layer of lipids, or “lipid bilayer,” that forms the structure, and a variety of embedded and attached proteins with highly specialized functions, including proteins that rapidly and selectively transport ions and molecules in and out of the cell.
![Edge computing is both dependent on and greatly influencing a host of promising technologies including (clockwise from top left): quantum computing; high-performance computing; neuromorphic computing; and carbon nanotubes.](/sites/default/files/styles/list_page_thumbnail/public/2020-02/Jones%20image%202-12-20.png?h=2e876d46&itok=fT3y4uz9)
We have a data problem. Humanity is now generating more data than it can handle; more sensors, smartphones, and devices of all types are coming online every day and contributing to the ever-growing global dataset.