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Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

Summer Widner, Stephanie Timbs, James Gaugler and James Avenell of ORNL are part of a team that processes thorium-228, a byproduct of actinium-227. As new uses for thorium are realized, particularly in medicine, the lab expects the demand for the radioisotope to grow.

As a medical isotope, thorium-228 has a lot of potential — and Oak Ridge National Laboratory produces a lot.

ORNL used novel additive manufacturing techniques to 3D print channel fasteners for Framatome’s boiling water reactor fuel assembly. Four components, like the one shown here, were installed at the TVA Browns Ferry nuclear plant. Credit: Framatome

Four first-of-a-kind 3D-printed fuel assembly brackets, produced at the Department of Energy’s Manufacturing Demonstration Facility at Oak Ridge National Laboratory, have been installed and are now under routine operating

ORNL researchers demonstrated a 3D printed power pole made of bioderived and recycled materials could be easily manufactured, transported and assembled, enabling the quick restoration of power after natural disasters. Credit: ORNL, U.S. Dept. of Energy

A team of researchers at Oak Ridge National Laboratory demonstrated the ability to additively manufacture power poles from bioderived and recycled materials, which could more quickly restore electricity after natural disasters.

ORNL researchers installed and demonstrated their wireless charging technology for the first time on an autonomous vehicle – the Local Motors Olli shuttle bus. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory researchers demonstrated their wireless charging technology on an autonomous electric vehicle for the first time in a project with Local Motors.

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.

ORNL researchers are developing a method to print low-cost, high-fidelity, customizable sensors for monitoring power grid equipment. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A method developed at Oak Ridge National Laboratory to print high-fidelity, passive sensors for energy applications can reduce the cost of monitoring critical power grid assets.

Pella Marion

A new Department of Energy report produced by Oak Ridge National Laboratory details national and international trends in hydropower, including the role waterpower plays in enhancing the flexibility and resilience of the power grid.

asset management

East Tennessee occupies a special place in nuclear history. In 1943, the world’s first continuously operating reactor began operating on land that would become ORNL.