Skip to main content
Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

ORNL researchers worked with partners at the Colorado School of Mines and Baylor University to develop a new process optimization and control method for a closed-circuit reverse osmosis desalination system. The work is intended to support fully automated, decentralized water treatment plants. Credit: Andrew Sproles/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists worked with the Colorado School of Mines and Baylor University to develop and test control methods for autonomous water treatment plants that use less energy and generate less waste.

An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

The Energy Exascale Earth System Model project reliably simulates aspects of earth system variability and projects decadal changes that will critically impact the U.S. energy sector in the future. A new version of the model delivers twice the performance of its predecessor. Credit: E3SM, Dept. of Energy

A new version of the Energy Exascale Earth System Model, or E3SM, is two times faster than an earlier version released in 2018.

This protein drives key processes for sulfide use in many microorganisms that produce methane, including Thermosipho melanesiensis. Researchers used supercomputing and deep learning tools to predict its structure, which has eluded experimental methods such as crystallography.  Credit: Ada Sedova/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory and the Georgia Institute of Technology is using supercomputing and revolutionary deep learning tools to predict the structures and roles of thousands of proteins with unknown functions.

ORNL’s Melissa Allen-Dumas examines the ways global and regional climate models can shed light on local climate effects and inform equitable solutions. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

The world is full of “huge, gnarly problems,” as ORNL research scientist and musician Melissa Allen-Dumas puts it — no matter what line of work you’re in. That was certainly the case when she would wrestle with a tough piece of music.

Burak Ozpineci is a globally recognized leader in power electronics research. He was named an ORNL Corporate Fellow in fall 2021. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Burak Ozpineci started out at ORNL working on a novel project: introducing silicon carbide into power electronics for more efficient electric vehicles. Twenty years later, the car he drives contains those same components.

Researchers from ORNL’s Vehicle and Autonomy Research Group created a control strategy for a hybrid electric bus that demonstrated up to 30% energy savings. Credit: University of California, Riverside

Oak Ridge National Laboratory researchers developed and demonstrated algorithm-based controls for a hybrid electric bus that yielded up to 30% energy savings compared with existing controls.

A traffic-camera view of Shallowford Road, one of the more than 350 intersections in Chattanooga studied by Oak Ridge National Laboratory researchers.

The daily traffic congestion along the streets and interstate lanes of Chattanooga could be headed the way of the horse and buggy with help from ORNL researchers.

Deeksha Rastogi uses high-performance computing to understand the human impacts of climate change. Credit: Carlos Jones, ORNL/U.S. Dept. of Energy

An international problem like climate change needs solutions that cross boundaries, both on maps and among disciplines. Oak Ridge National Laboratory computational scientist Deeksha Rastogi embodies that approach.