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Media Contacts
![ORNL’s Adam Guss began adapting the SAGE gene editing tool to modify microbes in graduate school. Today, SAGE is rapidly accelerating the design of custom microbes for a variety of applications. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-03/GussPetri_2021-P05223_0.png?h=82f92a78&itok=tqHo8Y9C)
A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.
![Technology to retrofit nonpowered dams such as the Lake Sequoyah Dam in North Carolina could be tested before deploying to ensure performance and reliability. Credit: Scott DeNeale/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-12/Sequoyah%20png.png?h=3873714b&itok=rYD7mUje)
Researchers at Oak Ridge National Laboratory have identified a key need for future hydropower innovations – full-scale testing – to better inform developers and operators before making major investments.
![ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-11/Novstorytip_autism_0.png?h=707772c7&itok=6_DcjloQ)
ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.
![Conduit hydropower presents opportunities in every state. Credit: ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-10/Picture1.png?h=3fe30658&itok=8NCUQOmV)
Millions of miles of pipelines and conduits across the United States make up an intricate network of waterways used for municipal, agricultural and industrial purposes.
![ORNL’s Tomás Rush explores the secret lives of fungi and plants for insights into the interactions that determine plant health. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-10/Tomas%20Thumbnail.png?h=c6980913&itok=lhmIQFW4)
Tomás Rush began studying the mysteries of fungi in fifth grade and spent his college intern days tromping through forests, swamps and agricultural lands searching for signs of fungal plant pathogens causing disease on host plants.
![ORNL is studying how climate change may impact water availability for hydropower facilities such as the Shasta Dam and Lake in California. Credit: U.S. Bureau of Reclamation](/sites/default/files/styles/list_page_thumbnail/public/2022-09/Shasta%20Dam.png?h=2664774c&itok=F-QELlkQ)
ORNL has provided hydropower operators with new data to better prepare for extreme weather events and shifts in seasonal energy demands caused by climate change.
![Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.](/sites/default/files/styles/list_page_thumbnail/public/2022-09/bradykinin_1.png?h=53873e96&itok=iBwJwFaV)
A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.
![Scientists at ORNL have created a rhizosphere-on-a-chip research platform, a miniaturized environment to study the ecosystem around poplar tree roots for insights into plant health and soil carbon sequestration. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-08/Rhizosphere%20on%20a%20chip_thumbnail.jpg?h=036a71b7&itok=KImuFYmF)
Scientists at ORNL have created a miniaturized environment to study the ecosystem around poplar tree roots for insights into plant health and soil carbon sequestration.
![Earth Day](/sites/default/files/styles/list_page_thumbnail/public/2022-04/Earth%20image.png?h=8f74817f&itok=5rQ_su9Z)
Tackling the climate crisis and achieving an equitable clean energy future are among the biggest challenges of our time.
![ORNL scientists created a new microbial trait mapping process that improves on classical protoplast fusion techniques to identify the genes that trigger desirable genetic traits like improved biomass processing. Credit: Nathan Armistead/ORNL, U.S. Dept. of Energy. Reprinted with the permission of Oxford University Press, publisher of Nucleic Acids Research](/sites/default/files/styles/list_page_thumbnail/public/2022-04/Nucleic%20Cover%20Illustration.jpg?h=4a9d1e17&itok=iw81emAt)
ORNL scientists had a problem mapping the genomes of bacteria to better understand the origins of their physical traits and improve their function for bioenergy production.