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Molecular dynamics simulations of the Fs-peptide revealed the presence of at least eight distinct intermediate stages during the process of protein folding. The image depicts a fully folded helix (1), various transitional forms (2–8), and one misfolded state (9). By studying these protein folding pathways, scientists hope to identify underlying factors that affect human health.

Using artificial neural networks designed to emulate the inner workings of the human brain, deep-learning algorithms deftly peruse and analyze large quantities of data. Applying this technique to science problems can help unearth historically elusive solutions.

In ORNL’s Low Activation Materials Development and Analysis Laboratory, Field makes use of a transmission electron microscope to examine a sample made with a focused ion beam. He investigates the defects produced in a FeCrAl alloy bombarded with neutrons in HFIR. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy

Kevin Field at the Department of Energy’s Oak Ridge National Laboratory synthesizes and scrutinizes materials for nuclear power systems that must perform safely and efficiently over decades of irradiation.

To develop complex materials with superior properties, Vera Bocharova uses diverse methods including broadband dielectric spectroscopy. Credit: Oak Ridge National Laboratory, U.S. Dept. of Energy; photographer Jason Richards

Vera Bocharova at the Department of Energy’s Oak Ridge National Laboratory investigates the structure and dynamics of soft materials—polymer nanocomposites, polymer electrolytes and biological macromolecules—to advance materials and technologies for energy, medicine and other applications.

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While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.

Clarice Phelps

More than 70 years ago, United States Navy Captain Hyman Rickover learned the ins and outs of nuclear science and reactor technology at the Clinton Training School at what would eventually become the Department of Energy’s Oak Ridge National Laboratory. Rickover applied his knowl...

L-R, Researchers Nils Stenvig, Isabelle Snyder and Travis Smith are developing tools and deploying sensors to aid decision-making as Puerto Rico rebuilds and modernizes its power grid.

As Puerto Rico works to restore and modernize its power grid after last year’s devastating hurricane season, researchers at Oak Ridge National Laboratory have stepped up to provide unique analysis, sensing and modeling tools to better inform decisions.

Default image of ORNL entry sign

If you ask the staff and researchers at the Department of Energy’s Oak Ridge National Laboratory how they were first referred to the lab, you will get an extremely varied list of responses. Some may have come here as student interns, some grew up in the area and knew the lab by ...

Sergei Kalinin, director of the Institute for Functional Imaging of Materials at Oak Ridge National Laboratory, convenes experts in microscopy and computing to gain scientific insights that will inform design of advanced materials for energy and informati

Sergei Kalinin of the Department of Energy’s Oak Ridge National Laboratory knows that seeing something is not the same as understanding it. As director of ORNL’s Institute for Functional Imaging of Materials, he convenes experts in microscopy and computing to gain scientific insigh...

Lauren Garrison

The materials inside a fusion reactor must withstand one of the most extreme environments in science, with temperatures in the thousands of degrees Celsius and a constant bombardment of neutron radiation and deuterium and tritium, isotopes of hydrogen, from the volatile plasma at th...

Schematic drawing of the boron nitride cell. Credit: University of Illinois at Chicago.

A new microscopy technique developed at the University of Illinois at Chicago allows researchers to visualize liquids at the nanoscale level — about 10 times more resolution than with traditional transmission electron microscopy — for the first time. By trapping minute amounts of...