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Oak Ridge National Laboratory led a team of scientists to design a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and future virus outbreaks. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

An illustration of the long-term evolution likely to occur as rising temperatures and subsequent thawing of frozen Arctic soils affects the northern Alaska tundra, as predicted by a high-performance model created by Oak Ridge National Laboratory. Credit: Adam Malin and Ethan Coon, ORNL/U.S. Dept. of Energy

Oak Ridge National Laboratory scientists set out to address one of the biggest uncertainties about how carbon-rich permafrost will respond to gradual sinking of the land surface as temperatures rise.

Oak Ridge National Laboratory’s Dave Weston works in a chamber at the DOE SPRUCE whole ecosystem experiment site in the peatlands of northern Minnesota. Credit: Kyle Pearson/ORNL, U.S. Dept. of Energy

A quest to understand how Sphagnum mosses facilitate the storage of vast amounts of carbon in peatlands led scientists to a surprising discovery: the plants have sex-based differences that appear to impact the carbon-storing process.

Jason Gardner, Sandra Davern and Peter Thornton have been elected fellows of AAAS. Credit: Laddy Fields/ORNL, U.S. Dept. of Energy

Three scientists from the Department of Energy’s Oak Ridge National Laboratory have been elected fellows of the American Association for the Advancement of Science, or AAAS.

Computational systems biologists at ORNL worked with the U.S. Department of Veterans Affairs and other institutions to identify 139 locations across the human genome tied to risk factors for varicose veins, marking a first step in the development of new treatments. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

As part of a multi-institutional research project, scientists at ORNL leveraged their computational systems biology expertise and the largest, most diverse set of health data to date to explore the genetic basis of varicose veins.

Seven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab. Credit: ORNL, U.S. Dept. of Energy

Seven scientists at the Department of Energy’s Oak Ridge National Laboratory have been named Battelle Distinguished Inventors, in recognition of their obtaining 14 or more patents during their careers at the lab.

Eight ORNL scientists are among the world’s most highly cited researchers, Credit: Butch Newton/ORNL, U.S. Dept. of Energy

Eight ORNL scientists are among the world’s most highly cited researchers, according to a bibliometric analysis conducted by the scientific publication analytics firm Clarivate.

Solar panels funded by the Honnold Foundation are installed in Adjuntas, Puerto Rico. Credit: Fabio Andrade

When Hurricane Maria battered Puerto Rico in 2017, winds snapped trees and destroyed homes, while heavy rains transformed streets into rivers. But after the storm passed, the human toll continued to grow as residents struggled without electricity for months. Five years later, power outages remain long and frequent.

Technology Innovation Program

Five technologies invented by scientists at the Department of Energy’s Oak Ridge National Laboratory have been selected for targeted investment through ORNL’s Technology Innovation Program.

ORNL scientists identified four amino acids key to signaling pathways in the PAN protein domain. Mutating any of those four resulted in disruption of the signal that tells cancer cells to multiply and spread in humans. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

Researchers at ORNL have definitively linked the function of a specific domain of proteins important in plant-microbe biology to a cancer trigger in humans, knowledge that had eluded scientists for decades.