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Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL

OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.

(From left) ORNL Associate Laboratory Director for Computing and Computational Sciences Jeff Nichols; ORNL Health Data Sciences Institute Director Gina Tourassi; DOE Deputy Under Secretary for Science Thomas Cubbage; ORNL Task Lead for Biostatistics Blair Christian; and ORNL Research Scientist Ioana Danciu were invited to the White House to showcase an ORNL-developed digital tool aimed at better matching cancer patients with clinical trials.

OAK RIDGE, Tenn., March 4, 2019—A team of researchers from the Department of Energy’s Oak Ridge National Laboratory Health Data Sciences Institute have harnessed the power of artificial intelligence to better match cancer patients with clinical trials.

The Consortium for Advanced Simulation of Light Water Reactors uses its Virtual Environment for Reactor Applications (VERA) software for the modeling and simulation of various nuclear reactors, such as the Westinghouse AP1000 pressurized water reactor.

The Department of Energy’s Oak Ridge National Laboratory is collaborating with industry on six new projects focused on advancing commercial nuclear energy technologies that offer potential improvements to current nuclear reactors and move new reactor designs closer to deployment.

Amy Moore is a postdoctoral researcher in the Transportation Planning and Decision Science Group at ORNL.

Amy Moore has found that her pursuit of several degrees and certificates in a variety of subjects is serving her well as she uses her expertise in transportation planning, geographic information science, and information technology to develop intelligent mobility solutions at ORNL. ...

Radiochemical technicians David Denton and Karen Murphy use hot cell manipulators at Oak Ridge National Laboratory during the production of actinium-227.

The Department of Energy’s Oak Ridge National Laboratory is now producing actinium-227 (Ac-227) to meet projected demand for a highly effective cancer drug through a 10-year contract between the U.S. DOE Isotope Program and Bayer.

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Researchers used neutrons to probe a running engine at ORNL’s Spallation Neutron Source

This isotropic, neodymium-iron-boron bonded permanent magnet was 3D-printed at DOE’s Manufacturing Demonstration Facility at Oak Ridge National Laboratory.

Researchers at the Department of Energy’s Oak Ridge National Laboratory have demonstrated that permanent magnets produced by additive manufacturing can outperform bonded magnets made using traditional techniques while conserving critical materials. Scientists fabric...

ORNL Director Thom Mason (left) and Thomas Roberts of Oddello Industries LLC sign a research and development agreement.

A process developed at Oak Ridge National Laboratory for large-scale recovery of rare earth magnets from used computer hard drives will undergo industrial testing under a new agreement between Oddello Industries LLC and ORNL, as part of the Department of Energy’s Crit...

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A new technology developed by the U.S. Department of Energy’s Critical Materials Institute that aids in the recycling, recovery and extraction of rare earth minerals has been licensed to U.S. Rare Earths, Inc.