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Analyses of lung fluid cells from COVID-19 patients conducted on the nation’s fastest supercomputer point to gene expression patterns that may explain the runaway symptoms produced by the body’s response to SARS-CoV-2. Credit: Jason B. Smith/ORNL, U.S. Dept. of Energy

A team led by Dan Jacobson of Oak Ridge National Laboratory used the Summit supercomputer at ORNL to analyze genes from cells in the lung fluid of nine COVID-19 patients compared with 40 control patients.

Sergei Kalinin

Five researchers at the Department of Energy’s Oak Ridge National Laboratory have been named ORNL Corporate Fellows in recognition of significant career accomplishments and continued leadership in their scientific fields.

Computational biophysicist Ada Sedova is using experiments and high-performance computing to explore the properties of biological systems and predict their form and function, including research to accelerate drug discovery for COVID-19. Photo credit: Jason Richards, Oak Ridge National Laboratory, U.S. Dept. of Energy.

Ada Sedova’s journey to Oak Ridge National Laboratory has taken her on the path from pre-med studies in college to an accelerated graduate career in mathematics and biophysics and now to the intersection of computational science and biology

The protease protein is both shaped like a heart and functions as one, allowing the virus replicate and spread. Inhibiting the protease would block virus reproduction. Credit: Andrey Kovalevsky/ORNL, U.S. Dept. of Energy

A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.

Omar Demerdash

With the rise of the global pandemic, Omar Demerdash, a Liane B. Russell Distinguished Staff Fellow at ORNL since 2018, has become laser-focused on potential avenues to COVID-19 therapies.

Coronavirus research

Researchers at the Department of Energy’s Oak Ridge National Laboratory have used Summit, the world’s most powerful and smartest supercomputer, to identify 77 small-molecule drug compounds that might warrant further study in the fight

Scanning probe microscopes use an atom-sharp tip—only a few nanometers thick—to image materials on a nanometer length scale. The probe tip, invisible to the eye, is attached to a cantilever (pictured) that moves across material surfaces like the tone arm on a record player. Credit: Genevieve Martin/Oak Ridge National Laboratory; U.S. Dept. of Energy.

Liam Collins was drawn to study physics to understand “hidden things” and honed his expertise in microscopy so that he could bring them to light.

Costas Tsouris portrait

While Tsouris’ water research is diverse in scope, its fundamentals are based on basic science principles that remain largely unchanged, particularly in a mature field like chemical engineering.

Representatives from The University of Toledo and the U.S. Department of Energy’s Oak Ridge National Laboratory (ORNL) in Tennessee are teaming up to conduct collaborative automotive materials research.” Credit: University of Toledo

ORNL and The University of Toledo have entered into a memorandum of understanding for collaborative research.

Water and energy are inextricably linked, yet in our 20th-century water systems we use freshwater once then throw it away. With innovations designed to enhance desalination technologies, agricultural runoff, produced water from industry, and inland brackish groundwater that are now seen as untreatable could all be sources of clean, safe, and affordable water.

The National Alliance for Water Innovation, a partnership of the Department of Energy’s Oak Ridge National Laboratory, other national labs, university and private sector partners, has been awarded a five-year, $100 million Energy-Water Desalination Hub by DOE to address water security issues in the United States.