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Neutron experiments helped reveal the one-carbon enzymatic mechanism that synthesizes vital food sources for cancer cells that depend on vitamin B6, providing key insights into designing novel drugs to slow the spread of aggressive cancers. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at ORNL are now turning their drug design approach toward cancer. 

ORNL’s Fernanda Santos examines a soil sample at an NGEE Arctic field site in the Alaskan tundra in June 2022. Credit: Amy Breen, University of Alaska Fairbanks.

Wildfires are an ancient force shaping the environment, but they have grown in frequency, range and intensity in response to a changing climate. At ORNL, scientists are working on several fronts to better understand and predict these events and what they mean for the carbon cycle and biodiversity.

Upgrades to the particle accelerator enabling the record 1.7-megawatt beam power at the Spallation Neutron Source included adding 28 high-power radio-frequency klystrons (red tubes) to provide higher power for the accelerator. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

The Spallation Neutron Source at the Department of Energy's Oak Ridge National Laboratory set a world record when its particle accelerator beam operating power reached 1.7 megawatts, substantially improving on the facility’s original design capability.

Herwig shared the impacts of neutron science with Secretary of Energy Jennifer Granholm during a tour of SNS in November 2021. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Ken Herwig's scientific drive crystallized in his youth when he solved a tough algebra word problem in his head while tossing newspapers from his bicycle. He said the joy he felt in that moment as a teenager fueled his determination to conquer mathematical mysteries. And he did.

ORNL researchers have enabled standard raised pavement markers to transmit GPS information that helps autonomous driving features function better in remote areas or in bad weather. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Working with Western Michigan University and other partners, ORNL engineers are placing low-powered sensors in the reflective raised pavement markers that are already used to help drivers identify lanes. Microchips inside the markers transmit information to passing cars about the road shape to help autonomous driving features function even when vehicle cameras or remote laser sensing, called LiDAR, are unreliable because of fog, snow, glare or other obstructions.

ORNL researchers, from left, Yang Liu, Xiaohan Yang and Torik Islam, collaborated on the development of a new capability to insert multiple genes simultaneously for fast, efficient transformation of plants into better bioenergy feedstocks. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

In a discovery aimed at accelerating the development of process-advantaged crops for jet biofuels, scientists at ORNL developed a capability to insert multiple genes into plants in a single step.

Rigoberto Advincula

Rigoberto Advincula, a renowned scientist at ORNL and professor of Chemical and Biomolecular Engineering at the University of Tennessee, has won the Netzsch North American Thermal Analysis Society Fellows Award for 2023.

Jerry Parks leads the Molecular Biophysics group at ORNL, leveraging his expertise in computational chemistry and bioinformatics to unlock the inner workings of proteins—molecules that govern cellular structure and function and are essential to life. Credit: Genevieve Martin, ORNL/U.S. Dept. of Energy

When reading the novel Jurassic Park as a teenager, Jerry Parks found the passages about gene sequencing and supercomputers fascinating, but never imagined he might someday pursue such futuristic-sounding science.

Yue Yuan, Weinberg Distinguished Staff Fellow at ORNL, is researching ways to create new materials to help the environment. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

Growing up in China, Yue Yuan stood beneath the world’s largest hydroelectric dam, built to harness the world’s third-longest river. Her father brought her to Three Gorges Dam every year as it was being constructed across the Yangtze River so she could witness its progress.

Robert Wagner

SAE International has awarded ORNL Buildings and Transportation Science Division Director Robert Wagner with the SAE Medal of Honor for his dedication and support of the organization’s mission of advancing mobility solutions.