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Media Contacts
![Neutron experiments helped reveal the one-carbon enzymatic mechanism that synthesizes vital food sources for cancer cells that depend on vitamin B6, providing key insights into designing novel drugs to slow the spread of aggressive cancers. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-08/23-G04841_Cancer_Kovalevsky_zdh_0.png?h=27870e4a&itok=3NAoJh26)
After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at ORNL are now turning their drug design approach toward cancer.
![Innovation Crossroads cohort 7](/sites/default/files/styles/list_page_thumbnail/public/2023-08/IC-cohort7-1000px.png?h=b6717701&itok=dHzO-FYD)
Seven entrepreneurs will embark on a two-year fellowship as the seventh cohort of Innovation Crossroads kicks off this month at ORNL. Representing a range of transformative energy technologies, Cohort 7 is a diverse class of innovators with promising new companies.
![ORNL’s Fernanda Santos examines a soil sample at an NGEE Arctic field site in the Alaskan tundra in June 2022. Credit: Amy Breen, University of Alaska Fairbanks.](/sites/default/files/styles/list_page_thumbnail/public/2023-08/Fernanda_Nome_June2022.jpg?h=06de31ac&itok=VGxKV_uY)
Wildfires are an ancient force shaping the environment, but they have grown in frequency, range and intensity in response to a changing climate. At ORNL, scientists are working on several fronts to better understand and predict these events and what they mean for the carbon cycle and biodiversity.
![Upgrades to the particle accelerator enabling the record 1.7-megawatt beam power at the Spallation Neutron Source included adding 28 high-power radio-frequency klystrons (red tubes) to provide higher power for the accelerator. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-07/Klystrons1_0.jpg?h=6de9c450&itok=PbSmDYuy)
The Spallation Neutron Source at the Department of Energy's Oak Ridge National Laboratory set a world record when its particle accelerator beam operating power reached 1.7 megawatts, substantially improving on the facility’s original design capability.
![Frontier supercomputer](/sites/default/files/styles/list_page_thumbnail/public/2023-06/Frontier-logos_0.jpg?h=c6980913&itok=yuF5A0wj)
Innovations in artificial intelligence are rapidly shaping our world, from virtual assistants and chatbots to self-driving cars and automated manufacturing.
![ORNL seismic researcher Chengping Chai placed seismic sensors on the ground at various distances from an ORNL nuclear reactor to learn whether they could detect its operating state. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-06/2023-P03398.jpg?h=3e43625b&itok=TXK8tthh)
Like most scientists, Chengping Chai is not content with the surface of things: He wants to probe beyond to learn what’s really going on. But in his case, he is literally building a map of the world beneath, using seismic and acoustic data that reveal when and where the earth moves.
![ORNL and Enginuity researchers proved that a micro combined heat and power prototype, or mCHP, with an opposed piston engine can achieve more than 93% overall energy efficiency. The environmentally friendly mCHP can replace a back-up generator or traditional hot water heater. Credit: ORNL, U.S. Department of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-06/storytipjb.png?h=ddb1ad0c&itok=0ZTdSit5)
ORNL researchers, in collaboration with Enginuity Power Systems, demonstrated that a micro combined heat and power prototype, or mCHP, with a piston engine can achieve an overall energy efficiency greater than 93%.
![ORNL researchers, from left, Yang Liu, Xiaohan Yang and Torik Islam, collaborated on the development of a new capability to insert multiple genes simultaneously for fast, efficient transformation of plants into better bioenergy feedstocks. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-06/Gene%20stacking%202023-P03111_0.jpg?h=c6980913&itok=RSUZXZ8U)
In a discovery aimed at accelerating the development of process-advantaged crops for jet biofuels, scientists at ORNL developed a capability to insert multiple genes into plants in a single step.
![Neutron scattering experiments at the Spallation Neutron Source revealed how the dynamics between copper and oxygen make a special type of enzyme excel at breaking down biomass. Insights could lead to lowering the cost of biofuel production. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-05/23-G02576_Meilleur_0.png?h=b6717701&itok=jPIOwV6b)
Nonfood, plant-based biofuels have potential as a green alternative to fossil fuels, but the enzymes required for production are too inefficient and costly to produce. However, new research is shining a light on enzymes from fungi that could make biofuels economically viable.
Oak Ridge National Laboratory scientists led the development of a supply chain model revealing the optimal places to site farms, biorefineries, pipelines and other infrastructure for sustainable aviation fuel production.