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![ORNL scientists developed a method that improves the accuracy of the CRISPR Cas9 gene editing tool used to modify microbes for renewable fuels and chemicals production. This research draws on the lab’s expertise in quantum biology, artificial intelligence and synthetic biology. Credit: Philip Gray/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-11/CRISPR%20Quantum%20AI_2_23-G07105-DOE-BER-BESSD-comms-graphic-pcg_2.jpg?h=847b7ff0&itok=WD2dBsAC)
Scientists at ORNL used their expertise in quantum biology, artificial intelligence and bioengineering to improve how CRISPR Cas9 genome editing tools work on organisms like microbes that can be modified to produce renewable fuels and chemicals.
![The OpeN-AM experimental platform, installed at the VULCAN instrument at ORNL’s Spallation Neutron Source, features a robotic arm that prints layers of molten metal to create complex shapes. This allows scientists to study 3D printed welds microscopically. Credit: Jill Hemman, ORNL/U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-10/VULCAN_welding_1.png?h=68c90eda&itok=gvwAQCpN)
Using neutrons to see the additive manufacturing process at the atomic level, scientists have shown that they can measure strain in a material as it evolves and track how atoms move in response to stress.
![Construction is underway at ORNL's Spallation Neutron Source. Credit: The Spallation Neutron Source at Oak Ridge National Laboratory — already the world’s most powerful accelerator-based neutron source — will be on a planned hiatus through June 2024 as crews work to upgrade the facility. Credit: Brett Riffert/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-09/Construction%20photo%20of%20tunnel%20stub%20work.jpg?h=46a45461&itok=7YoVs-O8)
The Spallation Neutron Source — already the world’s most powerful accelerator-based neutron source — will be on a planned hiatus through June 2024 as crews work to upgrade the facility. Much of the work — part of the facility’s Proton Power Upgrade project — will involve building a connector between the accelerator and the planned Second Target Station.
![Neutron experiments helped reveal the one-carbon enzymatic mechanism that synthesizes vital food sources for cancer cells that depend on vitamin B6, providing key insights into designing novel drugs to slow the spread of aggressive cancers. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-08/23-G04841_Cancer_Kovalevsky_zdh_0.png?h=27870e4a&itok=3NAoJh26)
After a highly lauded research campaign that successfully redesigned a hepatitis C drug into one of the leading drug treatments for COVID-19, scientists at ORNL are now turning their drug design approach toward cancer.
![Upgrades to the particle accelerator enabling the record 1.7-megawatt beam power at the Spallation Neutron Source included adding 28 high-power radio-frequency klystrons (red tubes) to provide higher power for the accelerator. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-07/Klystrons1_0.jpg?h=6de9c450&itok=PbSmDYuy)
The Spallation Neutron Source at the Department of Energy's Oak Ridge National Laboratory set a world record when its particle accelerator beam operating power reached 1.7 megawatts, substantially improving on the facility’s original design capability.
![An AI-generated image representing atoms and artificial neural networks. Credit: Maxim Ziatdinov, ORNL](/sites/default/files/styles/list_page_thumbnail/public/2023-04/atoms3.jpg?h=ab622562&itok=dNMzrFw8)
Researchers at ORNL have developed a machine-learning inspired software package that provides end-to-end image analysis of electron and scanning probe microscopy images.
![Paul Langan will oversee ORNL's research directorate focused on biological and environmental systems science. Credit: ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-12/2019-P15617_0.jpg?h=bf9cb32e&itok=4n50VPVf)
Paul Langan will join ORNL in the spring as associate laboratory director for the Biological and Environmental Systems Science Directorate.
![A pure lipid membrane formed using lipid-coated water droplets exhibits long-term potentiation, or LTP, associated with learning and memory, emulating hippocampal LTP observed in the brains of mammals and birds. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-12/22-G03904_Katsaras.png?h=e5aec6c8&itok=reSDZkmx)
While studying how bio-inspired materials might inform the design of next-generation computers, scientists at ORNL achieved a first-of-its-kind result that could have big implications for both edge computing and human health.
![Michelle Kidder received the lab’s Director’s Award for Outstanding Individual Accomplishment in Science and Technology for her decades-long work mentoring students, teachers and early-career staff. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-11/2018-P04785_0.png?h=7a8a8cdf&itok=hysTNqXX)
Laboratory Director Thomas Zacharia presented five Director’s Awards during Saturday night's annual Awards Night event hosted by UT-Battelle, which manages ORNL for the Department of Energy.
![Solar panels funded by the Honnold Foundation are installed in Adjuntas, Puerto Rico. Credit: Fabio Andrade](/sites/default/files/styles/list_page_thumbnail/public/2022-09/grid-thumb2.jpg?h=252f27fa&itok=p9gjQHsR)
When Hurricane Maria battered Puerto Rico in 2017, winds snapped trees and destroyed homes, while heavy rains transformed streets into rivers. But after the storm passed, the human toll continued to grow as residents struggled without electricity for months. Five years later, power outages remain long and frequent.