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Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

A new process developed by Oak Ridge National Laboratory leverages deep learning techniques to study cell movements in a simulated environment, guided by simple physics rules similar to video-game play. Credit: MSKCC and UTK

Scientists have developed a novel approach to computationally infer previously undetected behaviors within complex biological environments by analyzing live, time-lapsed images that show the positioning of embryonic cells in C. elegans, or roundworms. Their published methods could be used to reveal hidden biological activity. 

ORNL’s Larry York studies how plant root traits contribute to crop productivity. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Biologist Larry York’s fascination with plant roots has spurred his research across four continents and inspired him to create accessible tools that enable others to explore the underground world.

Carrie Eckert

Carrie Eckert applies her skills as a synthetic biologist at ORNL to turn microorganisms into tiny factories that produce a variety of valuable fuels, chemicals and materials for the growing bioeconomy.

The ectomycorrhizal fungus Laccaria bicolor, shown in green, envelops the roots of a transgenic switchgrass plant. Switchgrass is not known to interact with this type of fungi naturally; the added PtLecRLK1 gene tells the plant to engage the fungus. Credit: ORNL, U.S. Dept. of Energy

An ORNL team has successfully introduced a poplar gene into switchgrass, an important biofuel source, that allows switchgrass to interact with a beneficial fungus, ultimately boosting the grass’ growth and viability in changing environments.

ORNL metabolic engineer Adam Guss develops genetic tools to modify microbes that can perform a range of processes needed to create sustainable biofuels and bioproducts. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

As a metabolic engineer at Oak Ridge National Laboratory, Adam Guss modifies microbes to perform the diverse processes needed to make sustainable biofuels and bioproducts.

A team of scientists found that microbes at the SPRUCE experiment in the Minnesota peatlands are increasing production of methane under warming conditions. Credit: ORNL, U.S. Dept. of Energy

Scientists studying a unique whole-ecosystem warming experiment in the Minnesota peatlands found that microorganisms are increasing methane production faster than carbon dioxide production. 

The REVISE-II modeling tool developed at ORNL supports decision-making for electric vehicle charging infrastructure development along interstate highways in support of intercity travel. Credit: Jason Richards/ORNL, U.S. Dept. of Energy

Researchers at Oak Ridge National Laboratory have developed a nationwide modeling tool to help infrastructure planners decide where and when to locate electric vehicle charging stations along interstate highways. The goal is to encourage the adoption of EVs for cross-country travel.

Brian Davison portrait

In a long career full of scientific accomplishments, Brian Davison counts among his many successes the formation of ORNL’s LGBTQIA+ employee group and helping gay and lesbian staff at the lab

Scientists genetically engineered bacteria for itaconic acid production, creating dynamic controls that separate microbial growth and production phases for increased efficiency and acid yield. Credit: NREL

A research team led by Oak Ridge National Laboratory bioengineered a microbe to efficiently turn waste into itaconic acid, an industrial chemical used in plastics and paints.