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Scientists conducted microbial DNA sampling at a Yellowstone National Park hot spring for a study sponsored by DOE’s Biological and Environmental Research program, the National Science Foundation and NASA. Credit: Mircea Podar/ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists studied hot springs on different continents and found similarities in how some microbes adapted despite their geographic diversity.

Chlorella Vulgaris

In the search for ways to fight methylmercury in global waterways, scientists at Oak Ridge National Laboratory discovered that some forms of phytoplankton are good at degrading the potent neurotoxin.

ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

One of the proteins identified through a new ORNL-developed approach could be key to communications between poplar trees and beneficial microbes that can help boost poplar trees’ growth, carbon storage and climate resilience. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

ORNL researchers have identified specific proteins and amino acids that could control bioenergy plants’ ability to identify beneficial microbes that can enhance plant growth and storage of carbon in soils.

ORNL’s Adam Guss began adapting the SAGE gene editing tool to modify microbes in graduate school. Today, SAGE is rapidly accelerating the design of custom microbes for a variety of applications. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

A DNA editing tool adapted by Oak Ridge National Laboratory scientists makes engineering microbes for everything from bioenergy production to plastics recycling easier and faster.

Hybrid poplar trees such as these shown in an ORNL greenhouse were engineered with the REVEILLE1 gene to delay dormancy and produce more biomass. The research was led by the Center for Bioenergy Innovation at ORNL with the Joint Genome Institute, Brookhaven National Laboratory, the HudsonAlpha Institute for Biotechnology, the University of Connecticut and other partners. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

A team of scientists led by ORNL discovered the gene in agave that governs when the plant goes dormant and used it to create poplar trees that nearly doubled in size, increasing biomass yield for biofuels production

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Scientists used genome sequencing and computational biology to tease out the genetic profile of a new moss species, Sphagnum magni, typically found in the southeastern United States. Credit: Blanka Aguero, Duke University

A team from Oak Ridge National Laboratory, Duke University and other institutions studying Sphagnum moss have identified two new species in North America, and they are learning how evolution may affect the species’ role in carbon storage.

Thylakoid

A team of scientists led by Oak Ridge National Laboratory developed a theory that thylakoids, membrane networks key to plant photosynthesis, also function as a defense mechanism to harsh growing conditions, which could aid the development of hardier plants.

Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.