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Climate change often comes down to how it affects water, whether it’s for drinking, electricity generation, or how flooding affects people and infrastructure. To better understand these impacts, ORNL water resources engineer Sudershan Gangrade is integrating knowledge ranging from large-scale climate projections to local meteorology and hydrology and using high-performance computing to create a holistic view of the future.

Climate change often comes down to how it affects water, whether it’s for drinking, electricity generation, or how flooding affects people and infrastructure. To better understand these impacts, ORNL water resources engineer Sudershan Gangrade is integrating knowledge ranging from large-scale climate projections to local meteorology and hydrology and using high-performance computing to create a holistic view of the future.

ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

Oak Ridge National Laboratory led a team of scientists to design a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and future virus outbreaks. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Technology Innovation Program

Five technologies invented by scientists at the Department of Energy’s Oak Ridge National Laboratory have been selected for targeted investment through ORNL’s Technology Innovation Program.

ORNL biogeochemist Teri O’Meara is focused on improving how coastal systems are represented in global climate models, enabling better predictions about the future of these critical ecosystems. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Surrounded by the mountains of landlocked Tennessee, Oak Ridge National Laboratory’s Teri O’Meara is focused on understanding the future of the vitally important ecosystems lining the nation’s coasts.

Results show change in annual aridity for the years 2071-2100 compared to 1985-2014. Brown shadings (negative numbers) indicate drier conditions. Black dots indicate statistical significance at the 90% confidence level. Credit: Jiafu Mao/ORNL, U.S. Dept. of Energy

A new analysis from Oak Ridge National Laboratory shows that intensified aridity, or drier atmospheric conditions, is caused by human-driven increases in greenhouse gas emissions. The findings point to an opportunity to address and potentially reverse the trend by reducing emissions.

This protein drives key processes for sulfide use in many microorganisms that produce methane, including Thermosipho melanesiensis. Researchers used supercomputing and deep learning tools to predict its structure, which has eluded experimental methods such as crystallography.  Credit: Ada Sedova/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory and the Georgia Institute of Technology is using supercomputing and revolutionary deep learning tools to predict the structures and roles of thousands of proteins with unknown functions.

Carrie Eckert

Carrie Eckert applies her skills as a synthetic biologist at ORNL to turn microorganisms into tiny factories that produce a variety of valuable fuels, chemicals and materials for the growing bioeconomy.