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A 3D structure of the HIV-1 protease in cartoon representation with bound clinical drug darunavir (shown as sticks).
A team led by the Department of Energy’s Oak Ridge National Laboratory used neutron analysis to better understand a protein implicated in the replication of HIV, the retrovirus that causes AIDS. The enzyme, known as HIV-1 protease, is a key drug target for HIV and AIDS therapies. &nbs...
Illustration showing structure of Bi2Se3-EuS bilayer film. (Image credit: ORNL/Jill Hemman)
A multi-institutional team of researchers has discovered novel magnetic behavior on the surface of a specialized material that holds promise for smaller, more efficient devices and other advanced technology. Researchers at the Department of Energy’s Oak Ridge Natio...
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Four Oak Ridge National Laboratory researchers specializing in environmental, biological and computational science are among 49 recipients of Department of Energy's Office of Science Early Career Research Program awards. The Early Career Research Program, now in its ...

Interpreting the results of collision induced dissociation (CID) experiments, simulations on Titan predict the formation of an unusually bonded uranium-nitrosyl molecule. Credit: J. Am. Chem. Society. DOI: 10.1021/jacs.5b02420
Radioactive materials have long been a part of American history—from the Manhattan Project to the development of nuclear power. The materials central to these innovations are actinides, or elements 89–103 on the periodic table that release large amounts of energy when atoms are spli...
This rendering illustrates the excitation of a spin liquid on a honeycomb lattice using neutrons.

Researchers at the Department of Energy’s Oak Ridge National Laboratory used neutrons to uncover novel behavior in materials that holds promise for quantum computing. The findings, published in Nature Materials, provide evidence for long-sought phenomena in a two-dim...

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Lipid molecules have split personalities—one part loves water, whereas the other avoids it at all costs. Lipids make up cell membranes, the frontline defense in preventing cellular access to bacterial and viral invaders. Many researchers believe that the membrane is not just a scaf...
Knox County Commissioner and Oak Ridge National Laboratory Neutron Sciences Directorate employee Sam McKenzie talks to students from Knoxville’s Austin-East High School about career opportunities in science, technology, engineering and math during the
About 30 Austin-East High School students from Knoxville participated in the National “My Brother’s Keeper Day” at Oak Ridge National Laboratory. The goal of the White House initiative is designed to help boys and young men of color reach their full potential. ...
In pure water, lignin adopts a globular conformation (left) that aggregates on cellulose and blocks enzymes. In a THF-water cosolvent, lignin adopts coil conformations that are easier to remove during pretreatment. (ORNL image)
Breaking down cellulosic biomass for biofuel is a costly and complex process, requiring lots of acid, water, and heat. Experimental pretreatments, however, hold the promise of driving down these costs by making more biomass available to enzymes for fermentation. To gain a better...
New HPC4Mfg projects pair manufacturers with resources at Oak Ridge, Lawrence Berkeley and Lawrence Livermore national laboratories. From left to right are Robin Miles, LLNL; Horst Simon, LBNL; Peter Nugent, LBNL; Trish Damkroger, LLNL; Dona Crawford, LLN

The Department of Energy’s Oak Ridge National Laboratory will support four new industry projects announced today as part of DOE’s High Performance Computing for Manufacturing (HPC4Mfg) Program. The program pairs selected companies with national labs, including ORNL...

Researchers used experimental data to create a 23.7-million atom biomass model featuring cellulose (purple), lignin (brown), and enzymes (green). (Image credit: Mike Matheson, ORNL)
Ask a biofuel researcher to name the single greatest technical barrier to cost-effective ethanol, and you’re likely to receive a one-word response: lignin. Cellulosic ethanol—fuel derived from woody plants and waste biomass—has the potential to become an affordable, renew...