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The hCA II active site is flanked by hydrophilic (violet) and hydrophobic (green) binding pockets that can be used to design specific drugs targeting cancer-associated hCAs. Five clinical drugs are shown superimposed in the hCA II active site
New insights from neutron analysis of glaucoma drugs and their enzyme target may help scientists design drugs that more effectively target aggressive cancers. A team of researchers led by the Department of Energy’s Oak Ridge National Laboratory used neutro...
ORNL and EPRI built an enclosed welding system in a hot cell of ORNL’s Radiochemical Engineering Development Center. C. Scott White (ORNL) performs operations with remotely controlled manipulators and cameras.

Scientists of the Department of Energy’s Light Water Reactor Sustainability Program (LWRS) and partners from the Electric Power Research Institute (EPRI) have conducted the first weld tests to repair highly irradiated materials at DOE’s Oak Ridge National Laboratory.

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A team led by the Department of Energy’s Oak Ridge National Laboratory has uncovered how certain soil microbes cope in a phosphorus-poor environment to survive in a tropical ecosystem. Their novel approach could be applied in other ecosystems to study various nutrient limitations and inform agriculture and terrestrial biosphere modeling.
ORNL’s Steven Young (left) and Travis Johnston used Titan to prove the design and training of deep learning networks could be greatly accelerated with a capable computing system.

A team of researchers from the Department of Energy’s Oak Ridge National Laboratory has married artificial intelligence and high-performance computing to achieve a peak speed of 20 petaflops in the generation and training of deep learning networks on the

An example of a spiking neural network shows how data can be classified using the neuromorphic device. Credit: Catherine Schuman and Margaret Drouhard/Oak Ridge National Laboratory, U.S. Dept. of Energy
For smarter data management and analysis, researchers have developed a low-power neuromorphic device based on spiking neural networks that can quickly and more efficiently analyze and classify data.
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To improve models for drilling, hydraulic fracturing and underground storage of carbon dioxide, Oak Ridge National Laboratory scientists used neutrons to understand how water flows through fractured rock.
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A novel approach for studying magnetic behavior in a material called alpha-ruthenium trichloride may have implications for quantum computing. By suppressing the material’s magnetic order, scientists from Oak Ridge National Laboratory and the University of Tennessee observed be...
Inspired by the brain’s web of neurons, deep neural networks consist of thousands or millions of simple computational units.

Deep neural networks—a form of artificial intelligence—have demonstrated mastery of tasks once thought uniquely human. Their triumphs have ranged from identifying animals in images, to recognizing human speech, to winning complex strategy games, among other su...

Eugene Mamontov and the BASIS beam line at the Spallation Neutron Source at ORNL. Photo credit: Jason Richards, ORNL.
Eugene Mamontov’s background in both basic and applied science has made him a valued partner for scientists who come to the Spallation Neutron Source at ORNL in search of a better understanding of the water dynamics in their research—projects as diverse as studying plant cellulos...
The Department of Energy’s INCITE program promotes transformational advances in science and technology through large allocations of time on state-of-the-art supercomputers.

The U.S. Department of Energy’s Office of Science announced 55 projects with high potential for accelerating discovery through its Innovative and Novel Computational Impact on Theory and Experiment (INCITE) program. The projects will share 5.95 billion core-hours on t...