Skip to main content
The hCA II active site is flanked by hydrophilic (violet) and hydrophobic (green) binding pockets that can be used to design specific drugs targeting cancer-associated hCAs. Five clinical drugs are shown superimposed in the hCA II active site
New insights from neutron analysis of glaucoma drugs and their enzyme target may help scientists design drugs that more effectively target aggressive cancers. A team of researchers led by the Department of Energy’s Oak Ridge National Laboratory used neutro...
ORNL and EPRI built an enclosed welding system in a hot cell of ORNL’s Radiochemical Engineering Development Center. C. Scott White (ORNL) performs operations with remotely controlled manipulators and cameras.

Scientists of the Department of Energy’s Light Water Reactor Sustainability Program (LWRS) and partners from the Electric Power Research Institute (EPRI) have conducted the first weld tests to repair highly irradiated materials at DOE’s Oak Ridge National Laboratory.

Fossil_energy_ORNL3.jpg
To improve models for drilling, hydraulic fracturing and underground storage of carbon dioxide, Oak Ridge National Laboratory scientists used neutrons to understand how water flows through fractured rock.
Neutrons-Exotic_particles.jpg
A novel approach for studying magnetic behavior in a material called alpha-ruthenium trichloride may have implications for quantum computing. By suppressing the material’s magnetic order, scientists from Oak Ridge National Laboratory and the University of Tennessee observed be...
Eugene Mamontov and the BASIS beam line at the Spallation Neutron Source at ORNL. Photo credit: Jason Richards, ORNL.
Eugene Mamontov’s background in both basic and applied science has made him a valued partner for scientists who come to the Spallation Neutron Source at ORNL in search of a better understanding of the water dynamics in their research—projects as diverse as studying plant cellulos...
Chlorite dismutase - Journal cover art reprinted with permission from ACS Catalysis, vol. 7, issue 11, November 3, 2017. Further permissions related to the material excerpted should be directed to the ACS.

A new study sheds light on a unique enzyme that could provide an eco-friendly treatment for chlorite-contaminated water supplies and improve water quality worldwide. An international team of researchers led by Christian Obinger from the University of Vienna used neutron analys...

Neutrons probed two mechanisms proposed to explain what happens when hydrogen gas flows over a cerium oxide (CeO2) catalyst that has been heated in an experimental chamber to different temperatures to change its oxidation state. The first mechanism sugges
Having the right tool for the job enabled scientists at the Department of Energy’s Oak Ridge National Laboratory and their collaborators to discover that a workhorse catalyst of vehicle exhaust systems—an “oxygen sponge” that can soak up oxygen from air and store it for later use in oxidation reactions—may also be a “hydrogen sponge.”
Bacteria containing enzymes called beta-lactamases, illustrated by the light blue cluster, break down antibiotics and allow bacterial infections to develop and spread through human cells (orange). A team from ORNL’s Neutron Sciences Directorate is using n
The discovery of penicillin almost 90 years ago ushered in the age of modern antibiotics, but the growth of antibiotic resistance means bacterial infections like pneumonia and tuberculosis are becoming more difficult to treat.
Professors Zhenzhen Yu (left) and Michael Joachim Andreassen use neutrons at HFIR’s NRSF2 to investigate residual stresses expected to occur in the welds of offshore underwater wind turbine foundations. (Credit: ORNL/Genevieve Martin)
Massive offshore structures like oil rigs and wind turbines are designed to withstand the myriad punishments oceans tend to mete out. However, over time, just the saltwater itself can significantly decrease the durability of a structure’s welds. That’s why professors Michael Jo...
ORNL’s Steven Dajnowicz (left) and Andrey Kovalevsky prepared a sample to begin neutron structural analysis of a vitamin B6-dependent protein using the IMAGINE beamline at ORNL’s High Flux Isotope Reactor. Results of the study could open avenues for new a
Scientists at the Department of Energy’s Oak Ridge National Laboratory have performed neutron structural analysis of a vitamin B6-dependent protein, potentially opening avenues for new antibiotics and drugs to battle diseases such as drug-resistant