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Neutron scattering experiments show electric charges, shown in red, blue and grey, in the SARS-CoV-2 main protease site where telaprevir binds to the structure. The experiments provide critical data for the design of small-molecule drugs to treat COVID-19. Credit: Jill Hemman and Michelle Lehman/ORNL, U.S. Dept. of Energy

Scientists have found new, unexpected behaviors when SARS-CoV-2 – the virus that causes COVID-19 – encounters drugs known as inhibitors, which bind to certain components of the virus and block its ability to reproduce.  

Martin Wissink of ORNL’s Buildings and Transportation Science Division applies neutrons and other diagnostic tools at Oak Ridge National Laboratory in pursuit of cleaner, sustainable and more flexible transportation technologies. Credit: Genevieve Martin/ORNL, U.S. Dept of Energy

For a researcher who started out in mechanical engineering with a focus on engine combustion, Martin Wissink has learned a lot about neutrons on the job

Small, 3D-printed neutron collimators, designed by ORNL’s Jamie Molaison, yield reduced costs and manufacturing times and could enable new types of experiments. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

The ExOne Company, the global leader in industrial sand and metal 3D printers using binder jetting technology, announced it has reached a commercial license agreement with Oak Ridge National Laboratory to 3D print parts in aluminum-infiltrated boron carbide.

ORNL is designing a neutronic research engine to evaluate new materials and designs for advanced vehicles using the facilities at the Spallation Neutron Source at ORNL. Credit: Jill Hemman/ORNL, U.S. Dept of Energy, and  Southwest Research Institute.

In the quest for advanced vehicles with higher energy efficiency and ultra-low emissions, ORNL researchers are accelerating a research engine that gives scientists and engineers an unprecedented view inside the atomic-level workings of combustion engines in real time.

Six ORNL scientists have been elected as fellows to the American Association for the Advancement of Science, or AAAS. Credit: ORNL, U.S. Dept. of Energy

Six ORNL scientists have been elected as fellows to the American Association for the Advancement of Science, or AAAS.

The first neutron structure of the SARS-CoV-2 main protease enzyme revealed unexpected electrical charges in the amino acids cysteine (negative) and histidine (positive), providing key data about the virus’s replication. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

An interactive visualization shows potential progression of BECCS to address carbon dioxide reduction goals. Credit: ORNL, U.S. Dept. of Energy

The combination of bioenergy with carbon capture and storage could cost-effectively sequester hundreds of millions of metric tons per year of carbon dioxide in the United States, making it a competitive solution for carbon management, according to a new analysis by ORNL scientists.

3D-printed 316L steel has been irradiated along with traditionally wrought steel samples. Researchers are comparing how they perform at various temperatures and varying doses of radiation. Credit: Jaimee Janiga/ORNL

It’s a new type of nuclear reactor core. And the materials that will make it up are novel — products of Oak Ridge National Laboratory’s advanced materials and manufacturing technologies.

Andrew Harter, pictured, and fellow ORNL staff members formed Horizon31 to build a set of products and services that provide customized unmanned vehicle control systems. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Horizon31, LLC has exclusively licensed a novel communication system that allows users to reliably operate unmanned vehicles such as drones from anywhere in the world using only an internet connection.

Enzyme activity during organophosphate poisoning

Pick your poison. It can be deadly for good reasons such as protecting crops from harmful insects or fighting parasite infection as medicine — or for evil as a weapon for bioterrorism. Or, in extremely diluted amounts, it can be used to enhance beauty.