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Media Contacts
![Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.](/sites/default/files/styles/list_page_thumbnail/public/2022-09/bradykinin_1.png?h=53873e96&itok=iBwJwFaV)
A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.
![Technology Innovation Program](/sites/default/files/styles/list_page_thumbnail/public/2022-08/TIPbg_0.jpg?h=a50b7bdc&itok=_3vRlbkP)
Five technologies invented by scientists at the Department of Energy’s Oak Ridge National Laboratory have been selected for targeted investment through ORNL’s Technology Innovation Program.
![Giri Prakash, director of the ARM Data Center, works with the latest ARM computing cluster at ORNL. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-06/Giri%20Prakash%202021-P08675_0.jpg?h=036a71b7&itok=4B1bQQD5)
The Atmospheric Radiation Measurement Data Center is shepherding changes to its operations to make the treasure trove of data more easily available accessible and useful to scientists studying Earth’s climate.
![An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-06/frame1.png?h=d1cb525d&itok=51pwBWyP)
An ORNL-led team comprising researchers from multiple DOE national laboratories is using artificial intelligence and computational screening techniques – in combination with experimental validation – to identify and design five promising drug therapy approaches to target the SARS-CoV-2 virus.
![Neutron scattering experiments show electric charges, shown in red, blue and grey, in the SARS-CoV-2 main protease site where telaprevir binds to the structure. The experiments provide critical data for the design of small-molecule drugs to treat COVID-19. Credit: Jill Hemman and Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-03/after_transprent_background-wFill.png?h=c71d0c67&itok=jGFt_Ggj)
Scientists have found new, unexpected behaviors when SARS-CoV-2 – the virus that causes COVID-19 – encounters drugs known as inhibitors, which bind to certain components of the virus and block its ability to reproduce.
![ORNL’s Cory Stuart is head of data systems and cybersecurity for the DOE Atmospheric Radiation Measurement user facility. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2021-04/2021-P00891.jpg?h=8f9cfe54&itok=ERem27zT)
Cory Stuart of ORNL applies his expertise as a systems engineer to ensure the secure and timely transfer of millions of measurements of Earth’s atmosphere, fueling science around the world.
![Paul Kent, shown above posing with Summit in April 2018, received the 2020 ORNL Director’s Award for Outstanding Individual Accomplishment in Science and Technology. Credit: ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-11/DA_Kent.jpg?h=48cf6540&itok=Ocw9WcgV)
The annual Director's Awards recognized four individuals and teams including awards for leadership in quantum simulation development and application on high-performance computing platforms, and revolutionary advancements in the area of microbial
![An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-11/dark_image_small.png?h=2e111cc1&itok=drKqW05b)
Experiments led by researchers at ORNL have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.
![coronavirus](/sites/default/files/styles/list_page_thumbnail/public/2020-11/coronavirus_top10%20%28002%29.png?h=997b30da&itok=7I6TjG_l)
NellOne Therapeutics has licensed a drug delivery system from the Department of Energy’s Oak Ridge National Laboratory that is designed to transport therapeutics directly to cells infected by SARS-CoV-2, the virus causing COVID-19.
![Data collection instruments at the North Pole](/sites/default/files/styles/list_page_thumbnail/public/2020-11/49464270498_a1ff680b23_o_0.jpg?h=8afd2337&itok=zh9gntwP)
Researchers at Oak Ridge National Laboratory were part of an international team that collected a treasure trove of data measuring precipitation, air particles, cloud patterns and the exchange of energy between the atmosphere and the sea ice.