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Neutron scattering experiments show electric charges, shown in red, blue and grey, in the SARS-CoV-2 main protease site where telaprevir binds to the structure. The experiments provide critical data for the design of small-molecule drugs to treat COVID-19. Credit: Jill Hemman and Michelle Lehman/ORNL, U.S. Dept. of Energy

Scientists have found new, unexpected behaviors when SARS-CoV-2 – the virus that causes COVID-19 – encounters drugs known as inhibitors, which bind to certain components of the virus and block its ability to reproduce.  

Verónica Melesse Vergara speaks with third and fourth graders at East Side Intermediate School in Brownsville. Credit: ORNL, U.S. Dept. of Energy

Twenty-seven ORNL researchers Zoomed into 11 middle schools across Tennessee during the annual Engineers Week in February. East Tennessee schools throughout Oak Ridge and Roane, Sevier, Blount and Loudon counties participated, with three West Tennessee schools joining in.

The Perseverance rover

On Feb. 18, the world will be watching as NASA’s Perseverance rover makes its final descent into Jezero Crater on the surface of Mars. Mars 2020 is the first NASA mission that uses plutonium-238 produced at the Department of Energy’s Oak Ridge National Laboratory.

Distinguished Inventors

Six scientists at the Department of Energy’s Oak Ridge National Laboratory were named Battelle Distinguished Inventors, in recognition of obtaining 14 or more patents during their careers at the lab.

ORNL researchers in advanced manufacturing, materials science and engineering collaborated to produce face shields and reusable mask molds so that industry can quickly mass produce. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy

The University of Texas at San Antonio (UTSA) has formally launched the Cybersecurity Manufacturing Innovation Institute (CyManII), a $111 million public-private partnership.

The first neutron structure of the SARS-CoV-2 main protease enzyme revealed unexpected electrical charges in the amino acids cysteine (negative) and histidine (positive), providing key data about the virus’s replication. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy

To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.

ORNL researchers and energy storage startup Sparkz have developed a cobalt-free cathode material for use in lithium-ion batteries Credit: Ilias Belharouak/Oak Ridge National Laboratory, U.S. Dept. of Energy

Four research teams from the Department of Energy’s Oak Ridge National Laboratory and their technologies have received 2020 R&D 100 Awards.

ORNL researchers developed a quantum, or squeezed, light approach for atomic force microscopy that enables measurement of signals otherwise buried by noise. Credit: Raphael Pooser/ORNL, U.S. Dept. of Energy

Researchers at ORNL used quantum optics to advance state-of-the-art microscopy and illuminate a path to detecting material properties with greater sensitivity than is possible with traditional tools.

Researcher Chase Joslin uses Peregrine software to monitor and analyze a component being 3D printed at the Manufacturing Demonstration Facility at ORNL. Credit: Luke Scime/ORNL, U.S. Dept. of Energy.

Oak Ridge National Laboratory researchers have developed artificial intelligence software for powder bed 3D printers that assesses the quality of parts in real time, without the need for expensive characterization equipment.

Enzyme activity during organophosphate poisoning

Pick your poison. It can be deadly for good reasons such as protecting crops from harmful insects or fighting parasite infection as medicine — or for evil as a weapon for bioterrorism. Or, in extremely diluted amounts, it can be used to enhance beauty.