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Media Contacts
![An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-11/dark_image_small.png?h=2e111cc1&itok=drKqW05b)
Experiments led by researchers at ORNL have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.
![The first neutron structure of the SARS-CoV-2 main protease enzyme revealed unexpected electrical charges in the amino acids cysteine (negative) and histidine (positive), providing key data about the virus’s replication. Credit: Jill Hemman/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-10/20-G01620_Protease_PR_proof2_0.jpg?h=3e3883a3&itok=XB_ZEDFQ)
To better understand how the novel coronavirus behaves and how it can be stopped, scientists have completed a three-dimensional map that reveals the location of every atom in an enzyme molecule critical to SARS-CoV-2 reproduction.
A collaboration between the ORNL and a Florida-based medical device manufacturer has led to the addition of 500 jobs in the Miami area to support the mass production of N95 respirator masks.
![Emma Betters Thumbnail](/sites/default/files/styles/list_page_thumbnail/public/2020-10/emma%20betters_sized.jpg?h=e91a75a9&itok=k1X4xVjl)
Growing up in Florida, Emma Betters was fascinated by rockets and for good reason. Any time she wanted to see a space shuttle launch from NASA’s nearby Kennedy Space Center, all she had to do was sit on her front porch.
![Cars and coronavirus](/sites/default/files/styles/list_page_thumbnail/public/2020-08/Transportation-Gauging_pandemic_impact_ORNL_0.jpg?h=4a7d1ed4&itok=Xqx4kknO)
Oak Ridge National Laboratory researchers have developed a machine learning model that could help predict the impact pandemics such as COVID-19 have on fuel demand in the United States.
![Joe Hagerman is expanding connected neighborhood research at ORNL and envisions buildings of the future as resources capable of managing the flow and exchange of energy based on economic and market signals – a concept known as transactive energy. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Department of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-07/2020-P08672%5B2%5D_1.jpg?h=8f9cfe54&itok=CFroD1Y2)
Joe Hagerman, ORNL research lead for buildings integration and controls, understands the impact building technology innovations can have during times of crisis. Over a decade ago, he found himself in the middle of one of the most devastating natural disasters of the century, Hurricane Katrina.
![Computational biophysicist Ada Sedova is using experiments and high-performance computing to explore the properties of biological systems and predict their form and function, including research to accelerate drug discovery for COVID-19. Photo credit: Jason Richards, Oak Ridge National Laboratory, U.S. Dept. of Energy.](/sites/default/files/styles/list_page_thumbnail/public/2020-07/2017-P06162Cropped.jpg?h=f1d4573a&itok=TrvR_opt)
Ada Sedova’s journey to Oak Ridge National Laboratory has taken her on the path from pre-med studies in college to an accelerated graduate career in mathematics and biophysics and now to the intersection of computational science and biology
![The protease protein is both shaped like a heart and functions as one, allowing the virus replicate and spread. Inhibiting the protease would block virus reproduction. Credit: Andrey Kovalevsky/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-06/protease_dimer_3_1.png?h=aa51a450&itok=sJY7AB8d)
A team of researchers has performed the first room-temperature X-ray measurements on the SARS-CoV-2 main protease — the enzyme that enables the virus to reproduce.
![ORNL researchers are leading virtual STEM outreach activities, such as an Internet of Things demonstration in which participants in ORCSGirls control an LED board remotely.](/sites/default/files/styles/list_page_thumbnail/public/2020-06/200411_ogi_0055_0.jpg?h=28121b77&itok=ucPjaIJO)
COVID-19 has upended nearly every aspect of our daily lives and forced us all to rethink how we can continue our work in a more physically isolated world.
![Researchers at DOE’s Manufacturing Demonstration Facility at ORNL developed a reusable face mask prototype with injection molding that will enable industry to rapidly manufacture. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2020-05/2020-P03026_0.jpg?h=5d08f34f&itok=CbBMXqMW)
In the fight against the COVID-19 pandemic, it’s a race against the clock not only to find a vaccine but also to supply healthcare workers with life-saving equipment such as face shields, masks and test kits.