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Media Contacts
![Illustration of the intricate organization of the PKA structure, wherein different parts of the protein are connected through elaborate hydrogen bonding networks (dashed yellow lines), glued together by the hydrophobic assemblies (light blue and orange volumes)—all working together to build the functional active site. Insert shows protonation of the transferred phosphoryl group (cyan mesh) and its many interactions with water and the active site amino acid residues. Credit: Jill Hemman/ORNL](/sites/default/files/styles/list_page_thumbnail/public/2019-03/19-G00204_MR_graphic_Kovalevsky_proof5_2.png?h=b7fbb1a9&itok=wrZFNX-o)
OAK RIDGE, Tenn., March 20, 2019—Direct observations of the structure and catalytic mechanism of a prototypical kinase enzyme—protein kinase A or PKA—will provide researchers and drug developers with significantly enhanced abilities to understand and treat fatal diseases and neurological disorders such as cancer, diabetes, and cystic fibrosis.
![Neutron scattering allowed direct observation of how aurein induces lateral segregation in the bacteria membranes, which creates instability in the membrane structure. This instability causes the membranes to fail, making harmful bacteria less effective.](/sites/default/files/styles/list_page_thumbnail/public/2019-03/Neutrons-FightingSuperbugs_0.jpg?h=e4b73f5a&itok=ebOQD-Mr)
As the rise of antibiotic-resistant bacteria known as superbugs threatens public health, Oak Ridge National Laboratory’s Shuo Qian and Veerendra Sharma from the Bhaba Atomic Research Centre in India are using neutron scattering to study how an antibacterial peptide interacts with and fights harmful bacteria.
![Coexpression_hi-res_image[1].jpg Coexpression_hi-res_image[1].jpg](/sites/default/files/styles/list_page_thumbnail/public/Coexpression_hi-res_image%5B1%5D_0.jpg?itok=OnLe-krT)
While studying the genes in poplar trees that control callus formation, scientists at Oak Ridge National Laboratory have uncovered genetic networks at the root of tumor formation in several human cancers.
![Picture2.png Picture2.png](/sites/default/files/styles/list_page_thumbnail/public/Picture2_1.png?itok=IV4n9XEh)
Oak Ridge National Laboratory scientists studying fuel cells as a potential alternative to internal combustion engines used sophisticated electron microscopy to investigate the benefits of replacing high-cost platinum with a lower cost, carbon-nitrogen-manganese-based catalyst.
![Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing. Using as much as 50 percent lignin by weight, a new composite material created at ORNL is well suited for use in 3D printing.](/sites/default/files/styles/list_page_thumbnail/public/2018-P09551.jpg?itok=q7Ri01Qb)
Scientists at the Department of Energy’s Oak Ridge National Laboratory have created a recipe for a renewable 3D printing feedstock that could spur a profitable new use for an intractable biorefinery byproduct: lignin.
![2018-P07635 BL-6 user - Univ of Guelph-6004R_sm[2].jpg 2018-P07635 BL-6 user - Univ of Guelph-6004R_sm[2].jpg](/sites/default/files/styles/list_page_thumbnail/public/2018-P07635%20BL-6%20user%20-%20Univ%20of%20Guelph-6004R_sm%5B2%5D.jpg?itok=DUdZNt_q)
A team of scientists, led by University of Guelph professor John Dutcher, are using neutrons at ORNL’s Spallation Neutron Source to unlock the secrets of natural nanoparticles that could be used to improve medicines.
Scientists studying a valuable, but vulnerable, species of poplar have identified the genetic mechanism responsible for the species’ inability to resist a pervasive and deadly disease. Their finding, published in the Proceedings of the National Academy of Sciences, could lead to more successful hybrid poplar varieties for increased biofuels and forestry production and protect native trees against infection.
![Ryan Kerekes is leader of the RF, Communications, and Cyber-Physical Security Group at Oak Ridge National Laboratory. Photos by Genevieve Martin, ORNL. Ryan Kerekes is leader of the RF, Communications, and Cyber-Physical Security Group at Oak Ridge National Laboratory. Photos by Genevieve Martin, ORNL.](/sites/default/files/styles/list_page_thumbnail/public/Ryan%20Kerekes%20Profile%20lab1_0.jpg?itok=btnfhbaJ)
As leader of the RF, Communications, and Cyber-Physical Security Group at Oak Ridge National Laboratory, Kerekes heads an accelerated lab-directed research program to build virtual models of critical infrastructure systems like the power grid that can be used to develop ways to detect and repel cyber-intrusion and to make the network resilient when disruption occurs.
![The sensors measure parameters like temperature, chemicals and electric grid elements for industrial and electrical applications. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy The sensors measure parameters like temperature, chemicals and electric grid elements for industrial and electrical applications. Credit: Carlos Jones/Oak Ridge National Laboratory, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/drone%20inspecting%20EPB%20pole%20mounted%20transformers.jpg?itok=CiRIK4cC)
Brixon, Inc., has exclusively licensed a multiparameter sensor technology from the Department of Energy’s Oak Ridge National Laboratory. The integrated platform uses various sensors that measure physical and environmental parameters and respond to standard security applications.
![Oak Ridge National Laboratory launches Summit supercomputer. Oak Ridge National Laboratory launches Summit supercomputer.](/sites/default/files/styles/list_page_thumbnail/public/2018-P01537.jpg?itok=GLf4y1EZ)
The U.S. Department of Energy’s Oak Ridge National Laboratory today unveiled Summit as the world’s most powerful and smartest scientific supercomputer.