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An organic solvent and water separate and form nanoclusters on the hydrophobic and hydrophilic sections of plant material, driving the efficient deconstruction of biomass. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

Experiments led by researchers at ORNL have determined that several hepatitis C drugs can inhibit the SARS-CoV-2 main protease, a crucial protein enzyme that enables the novel coronavirus to reproduce.

coronavirus

NellOne Therapeutics has licensed a drug delivery system from the Department of Energy’s Oak Ridge National Laboratory that is designed to transport therapeutics directly to cells infected by SARS-CoV-2, the virus causing COVID-19.

Oak Ridge National Laboratory entrance sign

Geoffrey L. Greene, a professor at the University of Tennessee, Knoxville, who holds a joint appointment with ORNL, will be awarded the 2021 Tom Bonner Prize for Nuclear Physics from the American Physical Society.

The n-helium-3 precision experiment, conducted at ORNL, measured the weak force between protons and neutrons by detecting the tiny electrical signal produced when a neutron and a helium-3 nucleus combine and then decay as they move through the helium gas target cell. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

Through a one-of-a-kind experiment at ORNL, nuclear physicists have precisely measured the weak interaction between protons and neutrons. The result quantifies the weak force theory as predicted by the Standard Model of Particle Physics.

Xunxiang Hu, a Eugene P. Wigner Fellow in ORNL’s Materials Science and Technology Division, designed this machine to produce large, crack-free pieces of yttrium hydride to be used as a moderator in the core of ORNL’s Transformational Challenge Reactor and other microreactors. Credit: Xunxiang Hu/ORNL, U.S. Dept. of Energy

About 60 years ago, scientists discovered that a certain rare earth metal-hydrogen mixture, yttrium, could be the ideal moderator to go inside small, gas-cooled nuclear reactors.

ORNL researchers developed a quantum, or squeezed, light approach for atomic force microscopy that enables measurement of signals otherwise buried by noise. Credit: Raphael Pooser/ORNL, U.S. Dept. of Energy

Researchers at ORNL used quantum optics to advance state-of-the-art microscopy and illuminate a path to detecting material properties with greater sensitivity than is possible with traditional tools.

Simulation of short polymer chains

Oak Ridge National Laboratory scientists have discovered a cost-effective way to significantly improve the mechanical performance of common polymer nanocomposite materials.

Researchers at Oak Ridge National Laboratory shed new light on elusive chemical processes at the liquid-liquid interface during solvent extraction of cobalt (dark blue). Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

Real-time measurements captured by researchers at ORNL provide missing insight into chemical separations to recover cobalt, a critical raw material used to make batteries and magnets for modern technologies.

Analyses of lung fluid cells from COVID-19 patients conducted on the nation’s fastest supercomputer point to gene expression patterns that may explain the runaway symptoms produced by the body’s response to SARS-CoV-2. Credit: Jason B. Smith/ORNL, U.S. Dept. of Energy

A team led by Dan Jacobson of Oak Ridge National Laboratory used the Summit supercomputer at ORNL to analyze genes from cells in the lung fluid of nine COVID-19 patients compared with 40 control patients.

The CrossVis application includes a parallel coordinates plot (left), a tiled image view (right) and other interactive data views. Credit: Chad Steed/Oak Ridge National Laboratory, U.S. Dept. of Energy

From materials science and earth system modeling to quantum information science and cybersecurity, experts in many fields run simulations and conduct experiments to collect the abundance of data necessary for scientific progress.