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Media Contacts
![Computational systems biologists at ORNL worked with the U.S. Department of Veterans Affairs and other institutions to identify 139 locations across the human genome tied to risk factors for varicose veins, marking a first step in the development of new treatments. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2023-01/vein06_0.jpg?h=d32448e0&itok=ItaGWCo5)
As part of a multi-institutional research project, scientists at ORNL leveraged their computational systems biology expertise and the largest, most diverse set of health data to date to explore the genetic basis of varicose veins.
![A simulation of the planet from the DOE Energy Exascale Earth System Model, one of the large-scale models incorporated in the Earth System Grid Federation led by DOE’s Oak Ridge, Argonne and Lawrence Livermore national laboratories. Credit: LLNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-10/E3SM%20nAtlHurricanesTake2.0557_trsp.png?h=4fe6ae66&itok=WSM8rX_c)
The Earth System Grid Federation, a multi-agency initiative that gathers and distributes data for top-tier projections of the Earth’s climate, is preparing a series of upgrades.
![Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.](/sites/default/files/styles/list_page_thumbnail/public/2022-09/bradykinin_1.png?h=53873e96&itok=iBwJwFaV)
A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.
![Giri Prakash, director of the ARM Data Center, works with the latest ARM computing cluster at ORNL. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-06/Giri%20Prakash%202021-P08675_0.jpg?h=036a71b7&itok=4B1bQQD5)
The Atmospheric Radiation Measurement Data Center is shepherding changes to its operations to make the treasure trove of data more easily available accessible and useful to scientists studying Earth’s climate.
![Frontier has arrived, and ORNL is preparing for science on Day One. Credit: Carlos Jones/ORNL, Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-05/Frontier%20endcap.jpg?h=c6980913&itok=5i5DUzQz)
The Frontier supercomputer at the Department of Energy’s Oak Ridge National Laboratory earned the top ranking today as the world’s fastest on the 59th TOP500 list, with 1.1 exaflops of performance. The system is the first to achieve an unprecedented level of computing performance known as exascale, a threshold of a quintillion calculations per second.
![LandScan Global depicts population distribution estimates across the planet. The darker orange and red colors above indicate higher population density. Credit: ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-05/Picture1_0.jpg?h=9d172ced&itok=uYwYp-pW)
It’s a simple premise: To truly improve the health, safety, and security of human beings, you must first understand where those individuals are.
![The ORNL researchers’ findings may enable better detection of uranium tetrafluoride hydrate, a little-studied byproduct of the nuclear fuel cycle, and better understanding of how environmental conditions influence the chemical behavior of fuel cycle materials. Credit: Kevin Pastoor/Colorado School of Mines](/sites/default/files/styles/list_page_thumbnail/public/2022-05/UF4%20hydrate.png?h=d318f057&itok=spT-Dg48)
ORNL researchers used the nation’s fastest supercomputer to map the molecular vibrations of an important but little-studied uranium compound produced during the nuclear fuel cycle for results that could lead to a cleaner, safer world.
![Oak Ridge National Laboratory researchers quantified human behaviors during the early days of COVID-19, which could be useful for disaster response or city planning. Credit: Nathan Armistead/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-05/COVID%20human%20behavior_0.jpg?h=9fc2b970&itok=E7nSPBpk)
Researchers at Oak Ridge National Laboratory have empirically quantified the shifts in routine daytime activities, such as getting a morning coffee or takeaway dinner, following safer at home orders during the early days of the COVID-19 pandemic.
![Oak Ridge National Laboratory researchers built an Earth-to-space communications system to work with private and government partners with the goal of directly connecting data downlinks to high performance computing. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-05/Ground%20station%20satellite%20tip_0.jpg?h=9f252dc3&itok=p9Mk-hwp)
Oak Ridge National Laboratory is debuting a small satellite ground station that uses high-performance computing to support automated detection of changes to Earth’s landscape.
![ORNL, VA and Harvard researchers developed a sparse matrix full of anonymized information on what is thought to be the largest cohort of healthcare data used for this type of research in the U.S. The matrix can be probed with different methods, such as KESER, to gain new insights into human health. Credit: Nathan Armistead/ORNL, U.S. Dept. of Energy](/sites/default/files/styles/list_page_thumbnail/public/2022-04/2022-G00330_KESER%20Illustration_0.jpg?h=1cb48fc4&itok=c6ZuDdDg)
A team of researchers has developed a novel, machine learning–based technique to explore and identify relationships among medical concepts using electronic health record data across multiple healthcare providers.