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Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

High voltage power lines carry electricity generated by the Tennessee Valley Authority to ORNL. Credit: Dobie Gillispie/ORNL, U.S. Dept. of Energy

ORNL and the Tennessee Valley Authority, or TVA, are joining forces to advance decarbonization technologies from discovery through deployment through a new memorandum of understanding, or MOU.

An ORNL-led team studied the SARS-CoV-2 spike protein in the trimer state, shown here, to pinpoint structural transitions that could be disrupted to destabilize the protein and negate its harmful effects. Credit: Debsindhu Bhowmik/ORNL, U.S. Dept. of Energy

To explore the inner workings of severe acute respiratory syndrome coronavirus 2, or SARS-CoV-2, researchers from ORNL developed a novel technique.

ORNL Corporate Research Fellow and Geospatial Science and Human Security Division Director Budhu Bhaduri has been elected as a fellow of the American Association of Geographers. The honor recognizes Bhaduri for his “innovation, mentorship and wide-ranging leadership” in geographic sciences. Credit: ORNL, U.S. Dept. of Energy

ORNL’s Budhendra “Budhu” Bhaduri has been elected a fellow of the American Association of Geographers. The honor recognizes Bhaduri as “a world leader in innovation, development and application of research in human dynamics, geographic data science, remote sensing and scalable geocomputation.”

By studying the activity patterns of populations around the world, scientists at ORNL are identifying the communities that are most likely to face extreme climate events and associated national security challenges. Credit: Erik Schmidt/ORNL, U.S. Dept. of Energy

Using novel data sets and computing systems, researchers at ORNL are simulating how climate change affects the safety and security of the country. 

Watermarks, considered the most efficient mechanisms for tracking how complete streaming data processing is, allow new tasks to be processed immediately after prior tasks are completed. Image Credit: Nathan Armistead, ORNL

A team of collaborators from ORNL, Google Inc., Snowflake Inc. and Ververica GmbH has tested a computing concept that could help speed up real-time processing of data that stream on mobile and other electronic devices.

Biopsy from the tubular esophagus showing incomplete intestinal metaplasia, goblet cells with interposed cells having gastric foveolar-type mucin consistent with Barrett esophagus. Negative for dysplasia. H&E stain. Credit: Creative Commons

A team including researchers from the Department of Energy’s Oak Ridge National Laboratory has developed a digital tool to better monitor a condition known as Barrett’s esophagus, which affects more than 3 million people in the United States.

ORNL analytical chemists coupled a microextraction probe to a mass spectrometer for measurement of uranium isotope ratios from environmental swipes. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Analytical chemists at ORNL have developed a rapid way to measure isotopic ratios of uranium and plutonium collected on environmental swipes, which could help International Atomic Energy Agency analysts detect the presence of undeclared nuclear

Former ORNL Director Thom Mason presents Tom Kollie with a National Intelligence Meritorious Unit Citation on behalf of James Clapper, former director of national intelligence, and the national intelligence community in June 2017. Credit: Jason Richards/ORNL, U.S. Dept. of Energy

A 25-year career with the U.S. Navy, commanding combat missions overseas, brought Tom Kollie back to where he came from — ready to serve his country in a new way.

 

Summer Widner, Stephanie Timbs, James Gaugler and James Avenell of ORNL are part of a team that processes thorium-228, a byproduct of actinium-227. As new uses for thorium are realized, particularly in medicine, the lab expects the demand for the radioisotope to grow.

As a medical isotope, thorium-228 has a lot of potential — and Oak Ridge National Laboratory produces a lot.