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ORNL scientists mutated amino acids in a receptor protein, shown in green, which diminished interaction with the SARS-CoV-2 virus spike protein, shown in red. Mutating the receptor protein hampered the virus’s ability to infect host cells. Credit: ORNL, U.S. Dept. of Energy

Oak Ridge National Laboratory scientists exploring bioenergy plant genetics have made a surprising discovery: a protein domain that could lead to new COVID-19 treatments.

Oak Ridge National Laboratory led a team of scientists to design a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and future virus outbreaks. Credit: Michelle Lehman/ORNL, U.S. Dept. of Energy

A team of scientists led by the Department of Energy’s Oak Ridge National Laboratory designed a molecule that disrupts the infection mechanism of the SARS-CoV-2 coronavirus and could be used to develop new treatments for COVID-19 and other viral diseases.

A researcher works in a lab in the Radiochemical Engineering and Development Center, or REDC,  at ORNL’s main campus. The REDC provides world-class capabilities in isotope production, research and development, source fabrication, and the distribution of various unique isotopes. Here, experts handle some of the most exotic materials in the world. Credit: Carlos Jones, ORNL/U.S. Dept. of Energy

A series of new classes at Pellissippi State Community College will offer students a new career path — and a national laboratory a pipeline of workers who have the skills needed for its own rapidly growing programs.

ORNL’s award-winning ultraclean condensing high-efficiency natural gas furnace features an affordable add-on technology that can remove more than 99.9% of acidic gases and other emissions. The technology can also be added to other natural gas-driven equipment. Credit: Jill Hemman/ORNL

Natural gas furnaces not only heat your home, they also produce a lot of pollution. Even modern high-efficiency condensing furnaces produce significant amounts of corrosive acidic condensation and unhealthy levels of nitrogen oxides

Pm-147

With larger, purer shipments on a more frequent basis, Oak Ridge National Laboratory is moving closer to routine production of promethium-147. That’s thanks in part to the application of some specific research performed a decade ago for a completely different project.

Jason Gardner, Sandra Davern and Peter Thornton have been elected fellows of AAAS. Credit: Laddy Fields/ORNL, U.S. Dept. of Energy

Three scientists from the Department of Energy’s Oak Ridge National Laboratory have been elected fellows of the American Association for the Advancement of Science, or AAAS.

Nearly $500 million in Inflation Reduction Act funding will support several key science projects underway at ORNL. Credit: ORNL/U.S. Dept. of Energy

Several significant science and energy projects led by the ORNL will receive a total of $497 million in funding from the Inflation Reduction Act.

U.S. Secretary of Energy Jennifer Granholm visited Oak Ridge National Laboratory today to attend a groundbreaking ceremony for the U.S. Stable Isotope Research and Development Center. The facility is slated to receive $75 million in funding from the Inflation Reduction Act.

U.S. Secretary of Energy Jennifer Granholm visited Oak Ridge National Laboratory today to attend a groundbreaking ceremony for the U.S. Stable Isotope Production and Research Center. The facility is slated to receive $75 million in funding from the Inflation Reduction Act.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Researchers at Oak Ridge National Laboratory probed the chemistry of radium to gain key insights on advancing cancer treatments using radiation therapy. Credit: Adam Malin/ORNL, U.S. Dept. of Energy

Researchers at ORNL explored radium’s chemistry to advance cancer treatments using ionizing radiation.