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Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Yun-Yi Pai works with a closed-cycle dilution refrigerator designed for cryomagnetooptical microscopy at ORNL. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Five National Quantum Information Science Research Centers are leveraging the behavior of nature at the smallest scales to develop technologies for science’s most complex problems.

Travis Humble. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Travis Humble has been named director of the Quantum Science Center headquartered at ORNL. The QSC is a multi-institutional partnership that spans industry, academia and government institutions and is tasked with uncovering the full potential of quantum materials, sensors and algorithms.

The ORNL researchers’ findings may enable better detection of uranium tetrafluoride hydrate, a little-studied byproduct of the nuclear fuel cycle, and better understanding of how environmental conditions influence the chemical behavior of fuel cycle materials. Credit: Kevin Pastoor/Colorado School of Mines

ORNL researchers used the nation’s fastest supercomputer to map the molecular vibrations of an important but little-studied uranium compound produced during the nuclear fuel cycle for results that could lead to a cleaner, safer world.

Exploring the smallest distance scales with particle colliders often requires detailed calculations of the spectra of outgoing particles (smallest filled green circles). Image Credit: Benjamin Nachman, Berkeley Lab

Lawrence Berkeley National Laboratory physicists Christian Bauer, Marat Freytsis and Benjamin Nachman have leveraged an IBM Q quantum computer through the Oak Ridge Leadership Computing Facility’s Quantum Computing User Program to capture part of a

ORNL scientists created a new microbial trait mapping process that improves on classical protoplast fusion techniques to identify the genes that trigger desirable genetic traits like improved biomass processing. Credit: Nathan Armistead/ORNL, U.S. Dept. of Energy. Reprinted with the permission of Oxford University Press, publisher of Nucleic Acids Research

ORNL scientists had a problem mapping the genomes of bacteria to better understand the origins of their physical traits and improve their function for bioenergy production.

Dongarra in 2019 with Oak Ridge National Laboratory's Summit supercomputer

A force within the supercomputing community, Jack Dongarra developed software packages that became standard in the industry, allowing high-performance computers to become increasingly more powerful in recent decades.

ORNL’s Joseph Lukens runs experiments in an optics lab. Credit: Jason Richards/ORNL, U.S. Dept. of Energy

Scientists’ increasing mastery of quantum mechanics is heralding a new age of innovation. Technologies that harness the power of nature’s most minute scale show enormous potential across the scientific spectrum

Genetic analysis revealed connections between inflammatory activity and development of atomic dermatitis, according to researchers from the UPenn School of Medicine, the Perelman School of Medicine, and Oak Ridge National Laboratory. Credit: Kang Ko/UPenn

University of Pennsylvania researchers called on computational systems biology expertise at Oak Ridge National Laboratory to analyze large datasets of single-cell RNA sequencing from skin samples afflicted with atopic dermatitis.

Scientists from LanzaTech, Northwestern University and Oak Ridge National Laboratory engineered a microbe, shown in light blue, to convert molecules of industrial waste gases, such as carbon dioxide and carbon monoxide, into acetone. The same microbe can also make isopropanol. Credit: Andy Sproles/ORNL, U.S. Dept. of Energy

A team of scientists from LanzaTech, Northwestern University and ORNL have developed carbon capture technology that harnesses emissions from industrial processes to produce acetone and isopropanol