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ORNL researchers led by Michael Garvin, left, and David Kainer discovered genetic mutations called structural variants and linked them to autism spectrum disorders, demonstrating an approach that could be used to develop better diagnostics and drug therapies. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Genetic markers for autism, hiding in plain sight

ORNL researchers discovered genetic mutations that underlie autism using a new approach that could lead to better diagnostics and drug therapies.

Michelle Kidder received the lab’s Director’s Award for Outstanding Individual Accomplishment in Science and Technology for her decades-long work mentoring students, teachers and early-career staff. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Kidder takes top award at ORNL’s Awards Night for leadership in mentoring

Laboratory Director Thomas Zacharia presented five Director’s Awards during Saturday night's annual Awards Night event hosted by UT-Battelle, which manages ORNL for the Department of Energy.

Matthew Craig’s research at ORNL is focused on how carbon cycles in and out of soils, a process that can have tremendous impact on the Earth’s climate. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Matthew Craig: Solving the mysteries of soil carbon storage

Matthew Craig grew up eagerly exploring the forest patches and knee-high waterfalls just beyond his backyard in central Illinois’ corn belt. Today, that natural curiosity and the expertise he’s cultivated in biogeochemistry and ecology are focused on how carbon cycles in and out of soils, a process that can have tremendous impact on the Earth’s climate.

ORNL’s Adam Guss and colleagues used synthetic biology to develop a custom microbe capable of converting deconstructed mixed plastic waste into valuable new materials. Credit: Carlos Jones/ORNL, U.S. Dept. of Energy

Bringing custom microbes to the business of recycling plastic

Scientists working on a solution for plastic waste have developed a two-step chemical and biological process to break down and upcycle mixed plastics into valuable bioproducts.

ORNL’s Tomás Rush explores the secret lives of fungi and plants for insights into the interactions that determine plant health. Credit: Genevieve Martin/ORNL, U.S. Dept. of Energy

Tomás Rush: Decoding the secret language of plants and fungi

Tomás Rush began studying the mysteries of fungi in fifth grade and spent his college intern days tromping through forests, swamps and agricultural lands searching for signs of fungal plant pathogens causing disease on host plants.

A simulation of the planet from the DOE Energy Exascale Earth System Model, one of the large-scale models incorporated in the Earth System Grid Federation led by DOE’s Oak Ridge, Argonne and Lawrence Livermore national laboratories. Credit: LLNL, U.S. Dept. of Energy

Project launched to contribute upgrades to Earth System Grid Federation global climate data system

The Earth System Grid Federation, a multi-agency initiative that gathers and distributes data for top-tier projections of the Earth’s climate, is preparing a series of upgrades.

Scientists used genome sequencing and computational biology to tease out the genetic profile of a new moss species, Sphagnum magni, typically found in the southeastern United States. Credit: Blanka Aguero, Duke University

Moss genome study identifies two new species

A team from Oak Ridge National Laboratory, Duke University and other institutions studying Sphagnum moss have identified two new species in North America, and they are learning how evolution may affect the species’ role in carbon storage.

Shown here is the structure of the NEMO protein. A team from ORNL conducted extensive molecular dynamics work on Summit by using both quantum mechanics and machine-learning methods to look at the binding affinity of NEMO and 3CLpro in humans and other species and to consider the structural models derived from the sequences of other coronaviruses. Image courtesy Nature Communications, Dan Jacobson/ORNL.

Lab experiments support COVID-19 bradykinin storm theory

A new paper published in Nature Communications adds further evidence to the bradykinin storm theory of COVID-19’s viral pathogenesis — a theory that was posited two years ago by a team of researchers at the Department of Energy’s Oak Ridge National Laboratory.

Researchers used quantum Monte Carlo calculations to accurately render the structure and electronic properties of germanium selenide, a semiconducting nanomaterial. Credit: Paul Kent/ORNL, U.S. Dept. of Energy

Improving materials for energy storage, generation

A multi-lab research team led by ORNL's Paul Kent is developing a computer application called QMCPACK to enable precise and reliable predictions of the fundamental properties of materials critical in energy research.

Technology Innovation Program

Five ORNL technologies identified for investment toward commercialization

Five technologies invented by scientists at the Department of Energy’s Oak Ridge National Laboratory have been selected for targeted investment through ORNL’s Technology Innovation Program.